HUGKISS group characteristics at exit and changes from entry (baseline) to exit
Variable . | Characteristics at exit . | Change from entry to exit . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intensive hydroxyurea . | Standard hydroxyurea . | . | Intensive hydroxyurea . | Standard hydroxyurea . | . | |||||
| n . | Median (IQR) . | n . | Median (IQR) . | P value . | n . | Median (IQR) . | n . | Median (IQR) . | P value . | |
| White blood cell count (×109/L) | 23 | 6.7 (5.9-7.5) | 19 | 8.4 (6.3-12.2) | .053∗ | 23 | −4.50 (−7.29 to −2.61) | 19 | −0.77 (−3.25 to 1.54) | < .001∗ |
| ANC (×109/L) | 23 | 1.8 (1.2-2.7) | 18 | 2.6 (1.7-3.7) | .016∗ | 23 | −1.43 (−2.49 to −0.52) | 18 | 0.35 (−0.36 to 1.20) | < .001∗ |
| Hb (g/dL) | 23 | 10.0 (9.6-11.5) | 19 | 9.9 (8.9-10.8) | .35 | 23 | 1.20 (0.40-1.90) | 19 | 0.40 (−0.10 to 1.20) | .033 |
| Mean corpuscular volume (fL) | 23 | 91.5 (86.7-97.4) | 19 | 85.2 (77.9-90.4) | .01 | 23 | 9.60 (7.60-16.60) | 19 | 8.00 (−0.40 to 9.50) | .011∗ |
| Mean corpuscular hemoglobin (pg) | 23 | 31.7 (30.1-34.2) | 19 | 28.9 (27.1-31.0) | .002 | 23 | 5.20 (3.20-6.55) | 19 | 2.40 (0.60-3.90) | .003 |
| Mean corpuscular Hb concentration (g/dL) | 23 | 35.1 (34.1-35.9) | 19 | 34.3 (33.1-34.8) | .012 | 23 | 1.10 (0.20-2.10) | 19 | 0.30 (−0.30 to 1.00) | .14∗ |
| ARC (×109/L) | 23 | 131.2 (94.2-169.1) | 19 | 177.0 (107.7-265.1) | .081∗ | 22 | −175.9 (−232.4 to −57.05) | 19 | −91.6 (−126.6 to −36) | .03 |
| Platelet count (×109/L) | 23 | 275.0 (190.0-342.0) | 19 | 255.0 (183.0-422.0) | .98∗ | 23 | −18 (−76 to 45) | 19 | −48 (−77 to 24) | .75∗ |
| Creatinine (mg/dL) | 23 | 0.3 (0.2-0.3) | 18 | 0.2 (0.2-0.3) | .63 | 23 | 0.03 (0.00-0.05) | 18 | 0.03 (0.01-0.07) | .87 |
| Total bilirubin (mg/dL) | 23 | 0.9 (0.7-1.8) | 17 | 1.2 (1.1-1.7) | .21∗ | 23 | −0.30 (-0.80 to −0.05) | 17 | 0.30 (0.00-0.50) | .001∗ |
| Lactate dehydrogenase (units/L) | 23 | 422 (359-538) | 18 | 435 (374-510) | .97∗ | 23 | −94 (−210 to −9) | 18 | 4.5 (−77 to 56) | .013 |
| Alanine aminotransferase (units per L) | 23 | 19.0 (15.0-25.0) | 17 | 16.0 (14.0-21.0) | .47 | 23 | −5.0 (−9.0 to −2.0) | 17 | −4.0 (−8.0 to 0.0) | .69∗ |
| HbF (%) | 23 | 38.8 (31.8-43.3) | 19 | 26.1 (25.0-30.9) | .002 | 23 | 8.0 (1.5-18.4) | 19 | 0.20 (−3.80 to 0.80) | < .001∗ |
| HbS (%) | 22 | 54.3 (51.8-61.5) | 19 | 65.6 (60.9-67.9) | < .001 | 22 | −9.95 (−17.3 to −2.2) | 19 | −0.40 (−2.3 to 2.3) | < .001∗ |
| Weight (kg) | 23 | 12.0 (10.6-13.1) | 19 | 11.0 (10.2-13.4) | .78∗ | 23 | 2.8 (2.4-3.1) | 19 | 2.8 (2.3-3.6) | .93 |
| Height (cm) | 23 | 84.0 (82.5-87.1) | 18 | 83.0 (80.2-90.3) | .54∗ | 23 | 12.0 (10.6-12.5) | 18 | 11.95 (9.0-14.5) | .58 |
| Head circumference (cm) | 19 | 49.0 (48.0-50.0) | 15 | 49.0 (46.3-49.7) | .12 | 17 | 2.9 (2.5-3.6) | 14 | 3.25 (2.5-3.5) | .37∗ |
| Hydroxyurea dose at exit, mg/kg per day | 23 | 28.1 (22.7-30.5) | 19 | 19.0 (18.3-20.0) | < .001∗ | 23 | 7.71 (2.20-10.56) | 19 | −1.02 (−1.70 to −0.02) | < .001∗ |
Variable . | Characteristics at exit . | Change from entry to exit . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intensive hydroxyurea . | Standard hydroxyurea . | . | Intensive hydroxyurea . | Standard hydroxyurea . | . | |||||
| n . | Median (IQR) . | n . | Median (IQR) . | P value . | n . | Median (IQR) . | n . | Median (IQR) . | P value . | |
| White blood cell count (×109/L) | 23 | 6.7 (5.9-7.5) | 19 | 8.4 (6.3-12.2) | .053∗ | 23 | −4.50 (−7.29 to −2.61) | 19 | −0.77 (−3.25 to 1.54) | < .001∗ |
| ANC (×109/L) | 23 | 1.8 (1.2-2.7) | 18 | 2.6 (1.7-3.7) | .016∗ | 23 | −1.43 (−2.49 to −0.52) | 18 | 0.35 (−0.36 to 1.20) | < .001∗ |
| Hb (g/dL) | 23 | 10.0 (9.6-11.5) | 19 | 9.9 (8.9-10.8) | .35 | 23 | 1.20 (0.40-1.90) | 19 | 0.40 (−0.10 to 1.20) | .033 |
| Mean corpuscular volume (fL) | 23 | 91.5 (86.7-97.4) | 19 | 85.2 (77.9-90.4) | .01 | 23 | 9.60 (7.60-16.60) | 19 | 8.00 (−0.40 to 9.50) | .011∗ |
| Mean corpuscular hemoglobin (pg) | 23 | 31.7 (30.1-34.2) | 19 | 28.9 (27.1-31.0) | .002 | 23 | 5.20 (3.20-6.55) | 19 | 2.40 (0.60-3.90) | .003 |
| Mean corpuscular Hb concentration (g/dL) | 23 | 35.1 (34.1-35.9) | 19 | 34.3 (33.1-34.8) | .012 | 23 | 1.10 (0.20-2.10) | 19 | 0.30 (−0.30 to 1.00) | .14∗ |
| ARC (×109/L) | 23 | 131.2 (94.2-169.1) | 19 | 177.0 (107.7-265.1) | .081∗ | 22 | −175.9 (−232.4 to −57.05) | 19 | −91.6 (−126.6 to −36) | .03 |
| Platelet count (×109/L) | 23 | 275.0 (190.0-342.0) | 19 | 255.0 (183.0-422.0) | .98∗ | 23 | −18 (−76 to 45) | 19 | −48 (−77 to 24) | .75∗ |
| Creatinine (mg/dL) | 23 | 0.3 (0.2-0.3) | 18 | 0.2 (0.2-0.3) | .63 | 23 | 0.03 (0.00-0.05) | 18 | 0.03 (0.01-0.07) | .87 |
| Total bilirubin (mg/dL) | 23 | 0.9 (0.7-1.8) | 17 | 1.2 (1.1-1.7) | .21∗ | 23 | −0.30 (-0.80 to −0.05) | 17 | 0.30 (0.00-0.50) | .001∗ |
| Lactate dehydrogenase (units/L) | 23 | 422 (359-538) | 18 | 435 (374-510) | .97∗ | 23 | −94 (−210 to −9) | 18 | 4.5 (−77 to 56) | .013 |
| Alanine aminotransferase (units per L) | 23 | 19.0 (15.0-25.0) | 17 | 16.0 (14.0-21.0) | .47 | 23 | −5.0 (−9.0 to −2.0) | 17 | −4.0 (−8.0 to 0.0) | .69∗ |
| HbF (%) | 23 | 38.8 (31.8-43.3) | 19 | 26.1 (25.0-30.9) | .002 | 23 | 8.0 (1.5-18.4) | 19 | 0.20 (−3.80 to 0.80) | < .001∗ |
| HbS (%) | 22 | 54.3 (51.8-61.5) | 19 | 65.6 (60.9-67.9) | < .001 | 22 | −9.95 (−17.3 to −2.2) | 19 | −0.40 (−2.3 to 2.3) | < .001∗ |
| Weight (kg) | 23 | 12.0 (10.6-13.1) | 19 | 11.0 (10.2-13.4) | .78∗ | 23 | 2.8 (2.4-3.1) | 19 | 2.8 (2.3-3.6) | .93 |
| Height (cm) | 23 | 84.0 (82.5-87.1) | 18 | 83.0 (80.2-90.3) | .54∗ | 23 | 12.0 (10.6-12.5) | 18 | 11.95 (9.0-14.5) | .58 |
| Head circumference (cm) | 19 | 49.0 (48.0-50.0) | 15 | 49.0 (46.3-49.7) | .12 | 17 | 2.9 (2.5-3.6) | 14 | 3.25 (2.5-3.5) | .37∗ |
| Hydroxyurea dose at exit, mg/kg per day | 23 | 28.1 (22.7-30.5) | 19 | 19.0 (18.3-20.0) | < .001∗ | 23 | 7.71 (2.20-10.56) | 19 | −1.02 (−1.70 to −0.02) | < .001∗ |
IQR, interquartile range. Bold values indicate statistical significance (P < 0.05).
Characteristics at exit and changes from entry to exit were compared using either the t test or exact Mann-Whitney/Wilcoxon test.