Vitamin C and vitamin D levels at diagnosis and during treatment
| . | Vitamin C/D supplementation . | P value . | Total . | |
|---|---|---|---|---|
| No . | Yes . | |||
| 262 (60.8) . | 169 (39.2) . | 431 (100.0) . | ||
| Vitamin C, diagnosis (mg/L) | ||||
| n/missing | NA | 145/24 | ||
| Median | 3.20 | |||
| IQR | (1.83-6.43) | |||
| Min; max | 0.47; 15.42 | |||
| <2.5, n (%) | 56 (38.6%) | |||
| ≥2.5, <4, n (%) | 27 (18.6%) | |||
| ≥4, <6.2, n (%) | 25 (17.2%) | |||
| ≥6.2, ≤10, n (%) | 27 (18.6%) | |||
| >10, n (%) | 10 (6.9%) | |||
| Postinduction vitamin C (mg/L) | ||||
| n/missing | NA | 97/72 | ||
| Median | 4.62 | |||
| IQR | (2.53-7.15) | |||
| Min; max | 0.18; 18.09 | |||
| <2.5, n (%) | 23 (23.7%) | |||
| ≥2.5, <4, n (%) | 20 (20.6%) | |||
| ≥4, <6.2, n (%) | 20 (20.6%) | |||
| ≥6.2, ≤10, n (%) | 20 (20.6%) | |||
| >10, n (%) | 14 (14.4%) | |||
| Vitamin D, diagnosis (ng/mL) | ||||
| n/missing | 91/171 | 157/12 | 248/183 | |
| Median | 16.00 | 18.00 | .514 | 17.00 |
| IQR | (10.00-27.00) | (14.00-24.00) | (12.00-24.50) | |
| Min; max | 4.00; 56.00 | 4.00; 42.00 | 4.00; 56.00 | |
| <12.5, n (%) | 33 (36.3%) | 34 (21.7%) | 67 (27.0%) | |
| ≥12.5, <30, n (%) | 37 (40.7%) | 103 (65.6%) | 140 (56.5%) | |
| ≥30, n (%) | 21 (23.1%) | 20 (12.7%) | 41 (16.5%) | |
| Postinduction vitamin D (mg/L) | ||||
| n/missing | NA | 112/57 | ||
| Median | 39.00 | |||
| IQR | (27.50-49.00) | |||
| Min; max | 5.00; 93.00 | |||
| <12.5, n (%) | 5 (4.5%) | |||
| ≥12.5, <30, n (%) | 28 (25%) | |||
| ≥30, n (%) | 79 (70.5%) | |||
| Pretransplant vitamin D (ng/mL) | ||||
| n/missing | 74/1 | 37/0 | 112/0 | |
| Median | 19.00 | 33.00 | <.0001 | 24.50 |
| IQR | (12.00-28.00) | (28.00-40.00) | (16.00-33.50) | |
| Min; max | 6.00; 51.00 | 17.00; 54.00 | 6.00; 54.00 | |
| <12.5, n (%) | 20 (27.0) | 0 (0.0) | <.0001 | 20 (17.9) |
| ≥12.5, <30, n (%) | 39 (52.7) | 11 (28.9) | 50 (44.6) | |
| ≥30, n (%) | 15 (20.3) | 27 (71.1) | 42 (37.5) | |
| Day-100 posttransplant vitamin D (ng/mL) | ||||
| n/missing | 68/7 | 31/6 | 99/13 | |
| Median | 41.50 | 41.00 | .906 | 41.00 |
| IQR | (33.50-48.00) | (33.00-49.00) | (33.00-48.00) | |
| Min; max | 7.00; 128.00 | 28.00; 75.00 | 7.00; 128.00 | |
| <12.5, n (%) | 2 (2.9%) | 0 (0.0%) | .675 | 2 (2.0%) |
| ≥12.5, <30, n (%) | 10 (14.7%) | 3 (9.7%) | 13 (13.1%) | |
| ≥30 ng/mL | 56 (82.4%) | 28 (90.3%) | 84 (84.8%) | |
| EOT vitamin D if no allo-SCT (ng/mL) | ||||
| n/missing | 22/124 | 46/59 | 68/183 | |
| Median | 21.00 | 30.50 | .044 | 29.00 |
| IQR | (12.00-32.00) | (25.00-38.00) | (19.50-35.50) | |
| Min; max | 5.00; 96.00 | 8.00; 64.00 | 5.00; 96.00 | |
| <12.5, n (%) | 6 (27.3) | 2 (4.3) | .012 | 8 (11.8) |
| ≥12.5, <30, n (%) | 9 (40.9) | 18 (39.1) | 27 (39.7) | |
| ≥30, n (%) | 7 (31.8) | 26 (56.5) | 33 (48.5) | |
| . | Vitamin C/D supplementation . | P value . | Total . | |
|---|---|---|---|---|
| No . | Yes . | |||
| 262 (60.8) . | 169 (39.2) . | 431 (100.0) . | ||
| Vitamin C, diagnosis (mg/L) | ||||
| n/missing | NA | 145/24 | ||
| Median | 3.20 | |||
| IQR | (1.83-6.43) | |||
| Min; max | 0.47; 15.42 | |||
| <2.5, n (%) | 56 (38.6%) | |||
| ≥2.5, <4, n (%) | 27 (18.6%) | |||
| ≥4, <6.2, n (%) | 25 (17.2%) | |||
| ≥6.2, ≤10, n (%) | 27 (18.6%) | |||
| >10, n (%) | 10 (6.9%) | |||
| Postinduction vitamin C (mg/L) | ||||
| n/missing | NA | 97/72 | ||
| Median | 4.62 | |||
| IQR | (2.53-7.15) | |||
| Min; max | 0.18; 18.09 | |||
| <2.5, n (%) | 23 (23.7%) | |||
| ≥2.5, <4, n (%) | 20 (20.6%) | |||
| ≥4, <6.2, n (%) | 20 (20.6%) | |||
| ≥6.2, ≤10, n (%) | 20 (20.6%) | |||
| >10, n (%) | 14 (14.4%) | |||
| Vitamin D, diagnosis (ng/mL) | ||||
| n/missing | 91/171 | 157/12 | 248/183 | |
| Median | 16.00 | 18.00 | .514 | 17.00 |
| IQR | (10.00-27.00) | (14.00-24.00) | (12.00-24.50) | |
| Min; max | 4.00; 56.00 | 4.00; 42.00 | 4.00; 56.00 | |
| <12.5, n (%) | 33 (36.3%) | 34 (21.7%) | 67 (27.0%) | |
| ≥12.5, <30, n (%) | 37 (40.7%) | 103 (65.6%) | 140 (56.5%) | |
| ≥30, n (%) | 21 (23.1%) | 20 (12.7%) | 41 (16.5%) | |
| Postinduction vitamin D (mg/L) | ||||
| n/missing | NA | 112/57 | ||
| Median | 39.00 | |||
| IQR | (27.50-49.00) | |||
| Min; max | 5.00; 93.00 | |||
| <12.5, n (%) | 5 (4.5%) | |||
| ≥12.5, <30, n (%) | 28 (25%) | |||
| ≥30, n (%) | 79 (70.5%) | |||
| Pretransplant vitamin D (ng/mL) | ||||
| n/missing | 74/1 | 37/0 | 112/0 | |
| Median | 19.00 | 33.00 | <.0001 | 24.50 |
| IQR | (12.00-28.00) | (28.00-40.00) | (16.00-33.50) | |
| Min; max | 6.00; 51.00 | 17.00; 54.00 | 6.00; 54.00 | |
| <12.5, n (%) | 20 (27.0) | 0 (0.0) | <.0001 | 20 (17.9) |
| ≥12.5, <30, n (%) | 39 (52.7) | 11 (28.9) | 50 (44.6) | |
| ≥30, n (%) | 15 (20.3) | 27 (71.1) | 42 (37.5) | |
| Day-100 posttransplant vitamin D (ng/mL) | ||||
| n/missing | 68/7 | 31/6 | 99/13 | |
| Median | 41.50 | 41.00 | .906 | 41.00 |
| IQR | (33.50-48.00) | (33.00-49.00) | (33.00-48.00) | |
| Min; max | 7.00; 128.00 | 28.00; 75.00 | 7.00; 128.00 | |
| <12.5, n (%) | 2 (2.9%) | 0 (0.0%) | .675 | 2 (2.0%) |
| ≥12.5, <30, n (%) | 10 (14.7%) | 3 (9.7%) | 13 (13.1%) | |
| ≥30 ng/mL | 56 (82.4%) | 28 (90.3%) | 84 (84.8%) | |
| EOT vitamin D if no allo-SCT (ng/mL) | ||||
| n/missing | 22/124 | 46/59 | 68/183 | |
| Median | 21.00 | 30.50 | .044 | 29.00 |
| IQR | (12.00-32.00) | (25.00-38.00) | (19.50-35.50) | |
| Min; max | 5.00; 96.00 | 8.00; 64.00 | 5.00; 96.00 | |
| <12.5, n (%) | 6 (27.3) | 2 (4.3) | .012 | 8 (11.8) |
| ≥12.5, <30, n (%) | 9 (40.9) | 18 (39.1) | 27 (39.7) | |
| ≥30, n (%) | 7 (31.8) | 26 (56.5) | 33 (48.5) | |
EOT, end of treatment; N/A, not available; SCT, stem cell transplantation.