Table 4. Summary of AEs of special... | American Society of Hematology

Table 4.

Summary of AEs of special interest (safety analysis set)

AE of special interest	MAGNOLIA study (N = 68)
AE of special interest	Any Grade AE	Grade ≥3 AE
Any AE of special interest	54 (79.4)	23 (33.8)
Infections	38 (55.9)	15 (22.1)
Opportunistic infections	3 (4.4)	2 (2.9)
Bleeding	28 (41.2)	1 (1.5)
Major hemorrhage∗	1 (1.5)	1 (1.5)
Second primary malignancies	5 (7.4)	3 (4.4)
Skin cancers	2 (2.9)	0
Neutropenia†	11 (16.2)	8 (11.8)
Thrombocytopenia‡	11 (16.2)	3 (4.4)
Anemia	4 (5.9)	2 (2.9)
Hypertension	3 (4.4)	2 (2.9)
Atrial fibrillation/flutter	2 (2.9)	1 (1.5)
Ventricular arrhythmia	1 (1.5)	0

AE of special interest	MAGNOLIA study (N = 68)
AE of special interest	Any Grade AE	Grade ≥3 AE
Any AE of special interest	54 (79.4)	23 (33.8)
Infections	38 (55.9)	15 (22.1)
Opportunistic infections	3 (4.4)	2 (2.9)
Bleeding	28 (41.2)	1 (1.5)
Major hemorrhage∗	1 (1.5)	1 (1.5)
Second primary malignancies	5 (7.4)	3 (4.4)
Skin cancers	2 (2.9)	0
Neutropenia†	11 (16.2)	8 (11.8)
Thrombocytopenia‡	11 (16.2)	3 (4.4)
Anemia	4 (5.9)	2 (2.9)
Hypertension	3 (4.4)	2 (2.9)
Atrial fibrillation/flutter	2 (2.9)	1 (1.5)
Ventricular arrhythmia	1 (1.5)	0

Data are number (%).

Defined as any serious or grade ≥3 bleed at any site, or central nervous system bleed of any grade.

“Neutropenia” included the terms “neutropenia” and “neutrophil count decreased.”

“Thrombocytopenia” included the terms “thrombocytopenia” and “platelet count decreased.”