Table 2. Response, early deaths, and... | American Society of Hematology

Table 2.

Response, early deaths, and rates of ASCT

	GO1	GO2	P value	OR (95% CI)
	n = 422 (%)	n = 422 (%)	P value	OR (95% CI)
Response
CR + CRi	346 (82)	342 (81)	.723	1.06 (0.75-1.52)
CR	306 (73)	305 (72)	.939	1.01 (0.75-1.37)
CRi	40 (10)	37 (9)	.720	1.1 (0.68-1.75)
CR after course 1	239 (57)	264 (63)	.079	0.78 (0.59-1.03)
CR + CRi after course 1	268 (64)	284 (67)	.247	0.85 (0.64-1.12)
Response including MRD status after course 1	N = 373 (%)∗	N = 372 (%)∗
CR + CRi	219 (59)	234 (63)	.241	0.84 (0.63-1.12)
CR + CRi MRD <0.1%†	171 (46)	194 (52)	.085	0.78 (0.58-1.03)
CR MRD <0.1%†	154 (41)	184 (50)	.025	0.72 (0.54-0.96)
CR + CRi MRD negative	144 (39)	158 (43)	.282	0.85 (0.64-1.14)
CR MRD negative	130 (35)	152 (41)	.091	0.78 (0.57-1.04)
Early death
Day 30	32 (8)	34 (8)	.797	0.94 (0.56-1.54)
Day 60	44 (10)	52 (12)	.386	0.83 (0.54-1.27)
ASCT	144 (34)	128 (30)	.239	1.19 (0.89-1.59)
Allograft in CR1	122 (29)	107 (25)	.215	1.22 (0.89-1.64)
Time to allograft in CR1. median (range) days‡	108 (0-462)	111 (16-342)	.349	—

	GO1	GO2	P value	OR (95% CI)
	n = 422 (%)	n = 422 (%)	P value	OR (95% CI)
Response
CR + CRi	346 (82)	342 (81)	.723	1.06 (0.75-1.52)
CR	306 (73)	305 (72)	.939	1.01 (0.75-1.37)
CRi	40 (10)	37 (9)	.720	1.1 (0.68-1.75)
CR after course 1	239 (57)	264 (63)	.079	0.78 (0.59-1.03)
CR + CRi after course 1	268 (64)	284 (67)	.247	0.85 (0.64-1.12)
Response including MRD status after course 1	N = 373 (%)∗	N = 372 (%)∗
CR + CRi	219 (59)	234 (63)	.241	0.84 (0.63-1.12)
CR + CRi MRD <0.1%†	171 (46)	194 (52)	.085	0.78 (0.58-1.03)
CR MRD <0.1%†	154 (41)	184 (50)	.025	0.72 (0.54-0.96)
CR + CRi MRD negative	144 (39)	158 (43)	.282	0.85 (0.64-1.14)
CR MRD negative	130 (35)	152 (41)	.091	0.78 (0.57-1.04)
Early death
Day 30	32 (8)	34 (8)	.797	0.94 (0.56-1.54)
Day 60	44 (10)	52 (12)	.386	0.83 (0.54-1.27)
ASCT	144 (34)	128 (30)	.239	1.19 (0.89-1.59)
Allograft in CR1	122 (29)	107 (25)	.215	1.22 (0.89-1.64)
Time to allograft in CR1. median (range) days‡	108 (0-462)	111 (16-342)	.349	—

χ² or exact test used to generate the P values. MRD measured by flow cytometry.

OR, odds ratio.

All patients not attaining CR/CRi (including day 30 deaths) + patients in CR/CRi with MRD data.

MRD <0.1%, MRD negative or detectable but <0.1%.

Wilcoxon rank-sum test is used to generate the P value.