Clinical classification of LCH
| Children . | |
|---|---|
| Clinical group . | Description . |
| Multisystem | Two or more systems involved |
| With risk organ involvement | Involvement of liver, spleen, or bone marrow |
| Without risk organ involvement | Without involvement of liver, spleen, or bone marrow |
| Single system | Only 1 system involved |
| Single site | Skin, bone, lymph node, thyroid, thymus |
| Multiple sites | Multifocal bone disease |
| Special site | Skull-base lesion with intracranial extension or vertebral lesion with intraspinal soft tissue extension |
| Pulmonary LCH | Isolated lung disease |
| CNS-LCH | Tumorous lesions |
| Neurodegenerative disease LACI LACS | |
| Adults | |
| Unifocal | Solitary lesion involving any organ |
| Single-system pulmonary | Isolated lung involvement, predominantly smoking related |
| Single-system multifocal | ≥1 lesion involving any organ |
| Multisystem | ≥2 organ/system involvement |
| Children . | |
|---|---|
| Clinical group . | Description . |
| Multisystem | Two or more systems involved |
| With risk organ involvement | Involvement of liver, spleen, or bone marrow |
| Without risk organ involvement | Without involvement of liver, spleen, or bone marrow |
| Single system | Only 1 system involved |
| Single site | Skin, bone, lymph node, thyroid, thymus |
| Multiple sites | Multifocal bone disease |
| Special site | Skull-base lesion with intracranial extension or vertebral lesion with intraspinal soft tissue extension |
| Pulmonary LCH | Isolated lung disease |
| CNS-LCH | Tumorous lesions |
| Neurodegenerative disease LACI LACS | |
| Adults | |
| Unifocal | Solitary lesion involving any organ |
| Single-system pulmonary | Isolated lung involvement, predominantly smoking related |
| Single-system multifocal | ≥1 lesion involving any organ |
| Multisystem | ≥2 organ/system involvement |