Screening laboratory testing for hereditary thrombophilia in patients with venous thromboembolism
| Hereditary thrombophilia |
| Factor V Leiden mutation (using PCR-based assay) |
| Prothrombin G20210 mutation (using PCR-based assay) |
| Protein C deficiency (functional amidolytic assay) |
| Free protein S antigen |
| Antithrombin deficiency (heparin cofactor assay, save for patients on oral factor Xa inhibitors in whom antithrombin antigen is recommended to prevent “false normal” levels) |
| Hereditary thrombophilia |
| Factor V Leiden mutation (using PCR-based assay) |
| Prothrombin G20210 mutation (using PCR-based assay) |
| Protein C deficiency (functional amidolytic assay) |
| Free protein S antigen |
| Antithrombin deficiency (heparin cofactor assay, save for patients on oral factor Xa inhibitors in whom antithrombin antigen is recommended to prevent “false normal” levels) |
PCR, polymerase chain reaction.