Comparison of DDX41 P/LP variants in cohorts of hematologic malignancies when compared with healthy controls (gnomAD)
| . | DDX41G or DDX41G/S (LP/P)/DDX41-WT . | P value (compared with gnomAD) . | Proportion of DDX41G/S pattern . |
|---|---|---|---|
| Population database (gnomAD) | 77/125 000∗ (0.06%) | N/A | N/A |
| AML | 106/2157 (4.9%) | < .00001 (χ2) | 93/106 (87.7%) |
| MDS | 108/2865 (3.8%) | < .00001 (χ2) | 88/108 (81.5%) |
| MPN | 3/741 (0.4%) | .01 (Fisher) | 0/3 (0%) |
| B-cell neoplasm | 8/954 (0.84%) | .00001 (Fisher) | 0/954 (0%) |
| Acute lymphoblastic leukemia | 1/453 (0.22%) | .25 (Fisher) | 0/453 (0%) |
| . | DDX41G or DDX41G/S (LP/P)/DDX41-WT . | P value (compared with gnomAD) . | Proportion of DDX41G/S pattern . |
|---|---|---|---|
| Population database (gnomAD) | 77/125 000∗ (0.06%) | N/A | N/A |
| AML | 106/2157 (4.9%) | < .00001 (χ2) | 93/106 (87.7%) |
| MDS | 108/2865 (3.8%) | < .00001 (χ2) | 88/108 (81.5%) |
| MPN | 3/741 (0.4%) | .01 (Fisher) | 0/3 (0%) |
| B-cell neoplasm | 8/954 (0.84%) | .00001 (Fisher) | 0/954 (0%) |
| Acute lymphoblastic leukemia | 1/453 (0.22%) | .25 (Fisher) | 0/453 (0%) |
N/A, not applicable.
Approximate value.