Table 2. Summary of adverse events... | American Society of Hematology

Table 2.

Summary of adverse events

Variables	1 = yes; 0 = no	All patients		Cumulative received dose of BV (mg/kg)						P value
		All patients		Intended CDB 14.4 mg/kg		Moderately reduced CDB of 10.5-14.1 mg/kg		Severely reduced CDB of 2.4-9.6 mg/kg
		N = 179	%	n = 81	%	n = 48	%	n = 50	%
Neutropenia grade ≥3	0	93	52	51	63	23	48	19	38	.0194
	1	84	47	30	37	23	48	31	62
Anemia grade ≥3	0	126	70	60	74	35	73	31	62	.2317
	1	51	28	21	26	11	23	19	38
Increase of ALT grade ≥3	0	171	96	80	99	44	92	47	94	.2865
	1	6	3	1	1	2	4	3	6
Increase of lipase grade ≥3	0	93	52	46	57	25	52	22	44	.1289
	1	4	2	1	1	0	0	3	6
Thrombocytopenia grade ≥3	0	167	93	77	95	45	94	45	90	.2546
	1	10	6	4	5	1	2	5	10
Constipation grade ≥3	0	159	89	68	84	41	85	50	100	.3515
	1	3	2	1	1	2	4	0	0
Nausea grade ≥3	0	152	85	68	84	39	81	45	90	.4496
	1	11	6	3	4	3	6	5	10
Vomiting grade ≥3	0	152	85	68	84	39	81	45	90	.2205
	1	9	5	2	2	2	4	5	10
Diarrhea grade ≥3	0	150	84	68	84	38	79	44	88	.1187
	1	10	6	2	2	2	4	6	12
Fatigue grade ≥3	0	155	87	70	86	39	81	46	92	.3785
	1	9	5	2	2	3	6	4	8
Neuropathy grade ≥3	0	144	80	67	83	38	79	39	78	.0073
	1	22	12	3	4	8	17	11	22
Pyrexia grade ≥3	0	158	88	69	85	39	81	50	100	.2516
	1	1	1	0	0	1	2	0	0
Abdominal pain grade ≥3	0	145	81	67	83	36	75	42	84	.0854
	1	15	8	3	4	4	8	8	16
Oral mucositis	0	155	87	67	83	39	81	49	98	1
	1	3	2	1	1	1	2	1	2

Variables	1 = yes; 0 = no	All patients		Cumulative received dose of BV (mg/kg)						P value
		All patients		Intended CDB 14.4 mg/kg		Moderately reduced CDB of 10.5-14.1 mg/kg		Severely reduced CDB of 2.4-9.6 mg/kg
		N = 179	%	n = 81	%	n = 48	%	n = 50	%
Neutropenia grade ≥3	0	93	52	51	63	23	48	19	38	.0194
	1	84	47	30	37	23	48	31	62
Anemia grade ≥3	0	126	70	60	74	35	73	31	62	.2317
	1	51	28	21	26	11	23	19	38
Increase of ALT grade ≥3	0	171	96	80	99	44	92	47	94	.2865
	1	6	3	1	1	2	4	3	6
Increase of lipase grade ≥3	0	93	52	46	57	25	52	22	44	.1289
	1	4	2	1	1	0	0	3	6
Thrombocytopenia grade ≥3	0	167	93	77	95	45	94	45	90	.2546
	1	10	6	4	5	1	2	5	10
Constipation grade ≥3	0	159	89	68	84	41	85	50	100	.3515
	1	3	2	1	1	2	4	0	0
Nausea grade ≥3	0	152	85	68	84	39	81	45	90	.4496
	1	11	6	3	4	3	6	5	10
Vomiting grade ≥3	0	152	85	68	84	39	81	45	90	.2205
	1	9	5	2	2	2	4	5	10
Diarrhea grade ≥3	0	150	84	68	84	38	79	44	88	.1187
	1	10	6	2	2	2	4	6	12
Fatigue grade ≥3	0	155	87	70	86	39	81	46	92	.3785
	1	9	5	2	2	3	6	4	8
Neuropathy grade ≥3	0	144	80	67	83	38	79	39	78	.0073
	1	22	12	3	4	8	17	11	22
Pyrexia grade ≥3	0	158	88	69	85	39	81	50	100	.2516
	1	1	1	0	0	1	2	0	0
Abdominal pain grade ≥3	0	145	81	67	83	36	75	42	84	.0854
	1	15	8	3	4	4	8	8	16
Oral mucositis	0	155	87	67	83	39	81	49	98	1
	1	3	2	1	1	1	2	1	2

ALT, alanine aminotransferase.