Flow cytometry features used in the diagnosis of putative MDS
| Features . | Use in diagnosis . |
|---|---|
| Blast percentage and immunophenotype in bone marrow | Documents blast immunophenotype (myeloid); report should specify how blasts are quantified |
| Aberrant blast immunophenotypes | Support a diagnosis of MDS already suspected based on other features |
| Aberrant immunophenotypes of granulocytes, monocytes, and erythroids | Support a diagnosis of MDS already suspected based on other features |
| Clonality of B cells | Evaluates for a B-cell lymphoma involving the bone marrow if lymphoma is suggested by morphology |
| T-cell immunophenotype | Evaluates for large granular lymphocytic leukemia or other T-cell lymphomas involving the bone marrow |
| Paroxysmal nocturnal hemoglobinuria assessment (blood) | Useful in hypocellular cases when aplastic anemia or paroxysmal nocturnal hemoglobinuria are considered as alternate diagnoses |
| Features . | Use in diagnosis . |
|---|---|
| Blast percentage and immunophenotype in bone marrow | Documents blast immunophenotype (myeloid); report should specify how blasts are quantified |
| Aberrant blast immunophenotypes | Support a diagnosis of MDS already suspected based on other features |
| Aberrant immunophenotypes of granulocytes, monocytes, and erythroids | Support a diagnosis of MDS already suspected based on other features |
| Clonality of B cells | Evaluates for a B-cell lymphoma involving the bone marrow if lymphoma is suggested by morphology |
| T-cell immunophenotype | Evaluates for large granular lymphocytic leukemia or other T-cell lymphomas involving the bone marrow |
| Paroxysmal nocturnal hemoglobinuria assessment (blood) | Useful in hypocellular cases when aplastic anemia or paroxysmal nocturnal hemoglobinuria are considered as alternate diagnoses |