Comparative MDS classification
| WHO revised fourth edition . | WHO fifth edition . | ICC . |
|---|---|---|
| MDS with RS (most SF3B1-mutated cases) | MDS with LB and SF3B1 mutation | MDS with mutated SF3B1 |
| MDS with RS (SF3B1 wild-type cases) | MDS with LB and RS | Not included |
| MDS with isolated del(5q) | MDS with LB and isolated 5q deletion | MDS with del(5q) |
| MDS with SLD | MDS with LB | MDS-NOS with SLD |
| MDS with MLD | MDS with LB | MDS-NOS with MLD |
| MDS, unclassifiable (most cases) | CCUS | MDS-NOS without dysplasia |
| Not included | MDS, hypoplastic | Not included |
| MDS with EB1 | MDS with IB1 | MDS with EB |
| MDS with EB2 | MDS with IB2 | MDS/AML |
| Not included | MDS with fibrosis | Not included |
| Not included | MDS with bi-allelic TP53 inactivation | MDS and MDS/AML with mutated TP53 |
| WHO revised fourth edition . | WHO fifth edition . | ICC . |
|---|---|---|
| MDS with RS (most SF3B1-mutated cases) | MDS with LB and SF3B1 mutation | MDS with mutated SF3B1 |
| MDS with RS (SF3B1 wild-type cases) | MDS with LB and RS | Not included |
| MDS with isolated del(5q) | MDS with LB and isolated 5q deletion | MDS with del(5q) |
| MDS with SLD | MDS with LB | MDS-NOS with SLD |
| MDS with MLD | MDS with LB | MDS-NOS with MLD |
| MDS, unclassifiable (most cases) | CCUS | MDS-NOS without dysplasia |
| Not included | MDS, hypoplastic | Not included |
| MDS with EB1 | MDS with IB1 | MDS with EB |
| MDS with EB2 | MDS with IB2 | MDS/AML |
| Not included | MDS with fibrosis | Not included |
| Not included | MDS with bi-allelic TP53 inactivation | MDS and MDS/AML with mutated TP53 |
CCUS, clonal cytopenia of undetermined significance; EB, excess blasts; IB, increased blasts; LB, low blasts; MLD, multilineage dysplasia; NOS, not otherwise specified; RS, ring sideroblasts; SLD, single lineage dysplasia.