Epigenetic clock values, residuals, and associations with various clinical characteristics
| . | Median (SD) . | Welch t test–P value . | Linear regressions–P value . | Pearson’s correlation coefficient - r (P value) . | ||||
|---|---|---|---|---|---|---|---|---|
| Biological sex . | SCD genotype . | β-globin haplotype . | SCD disease severity . | BCL11A SNP . | Chronological age . | Genetic ancestry . | ||
| DNAmAge (Horvath) age | 0.40 (4.48) | .89 | .61 | .28 | .93 | .99 | .88 (<1e-5)∗∗ | .212 (.057) |
| DNAmAge (Hannum) age | −3.98 (3.86) | .62 | .11 | .89 | .92 | .71 | .89 (<1e-5)∗∗ | .173 (.120) |
| PhenoAge age | −8.65 (6.00) | .23 | .02∗ | .34 | .90 | .26 | .85 (<1e-5)∗∗ | .092 (.411) |
| GrimAge age | 11.90 (4.02) | .96 | .19 | .52 | .67 | .69 | .88 (<1e-5∗)∗∗ | .176 (.114) |
| DunedinPACE rate | 1.14 (0.12) | .07 | <.001∗∗ | .41 | .56 | .79 | .34 (.001)∗∗ | .041 (.722) |
| DNAmAge (Horvath) residuals | 0.07 (4.50) | .25 | .61 | .29 | .83 | .54 | NA | .181 (.104) |
| DNAmAge (Hannum) residuals | 0.24 (3.78) | .96 | .07 | .30 | .54 | .87 | NA | −.001 (.994) |
| PhenoAge residuals | 0.08 (5.89) | .10 | .03∗ | .39 | .59 | .11 | NA | −.135 (.226) |
| GrimAge residuals | −0.30 (3.94) | .25 | .10 | .96 | .95 | .81 | NA | .015 (.894) |
| . | Median (SD) . | Welch t test–P value . | Linear regressions–P value . | Pearson’s correlation coefficient - r (P value) . | ||||
|---|---|---|---|---|---|---|---|---|
| Biological sex . | SCD genotype . | β-globin haplotype . | SCD disease severity . | BCL11A SNP . | Chronological age . | Genetic ancestry . | ||
| DNAmAge (Horvath) age | 0.40 (4.48) | .89 | .61 | .28 | .93 | .99 | .88 (<1e-5)∗∗ | .212 (.057) |
| DNAmAge (Hannum) age | −3.98 (3.86) | .62 | .11 | .89 | .92 | .71 | .89 (<1e-5)∗∗ | .173 (.120) |
| PhenoAge age | −8.65 (6.00) | .23 | .02∗ | .34 | .90 | .26 | .85 (<1e-5)∗∗ | .092 (.411) |
| GrimAge age | 11.90 (4.02) | .96 | .19 | .52 | .67 | .69 | .88 (<1e-5∗)∗∗ | .176 (.114) |
| DunedinPACE rate | 1.14 (0.12) | .07 | <.001∗∗ | .41 | .56 | .79 | .34 (.001)∗∗ | .041 (.722) |
| DNAmAge (Horvath) residuals | 0.07 (4.50) | .25 | .61 | .29 | .83 | .54 | NA | .181 (.104) |
| DNAmAge (Hannum) residuals | 0.24 (3.78) | .96 | .07 | .30 | .54 | .87 | NA | −.001 (.994) |
| PhenoAge residuals | 0.08 (5.89) | .10 | .03∗ | .39 | .59 | .11 | NA | −.135 (.226) |
| GrimAge residuals | −0.30 (3.94) | .25 | .10 | .96 | .95 | .81 | NA | .015 (.894) |
Associations between sex and sickle cell genotype (dichotomous continuous variables) were calculated using the Welch t tests. Associations with SCD severity, β-globin haplotype, and BCL11A SNP (polytomous ordinal variables) were calculated using linear regression. Associations between chronological age and genetic ancestry (continuous variables) were calculated using Pearson correlation coefficient. ∗P < 0.05; ∗∗P < 0.001.