AEs and SAEs observed in enrolled study patients
| . | SAEs (total 14 SAEs in 10 patients) . | |
|---|---|---|
| IQ (n = 23) . | Placebo (n = 23) . | |
| (8 SAEs in 6 patients) . | (6 SAEs in 4 patients) . | |
| SCA with VOC | 5 | 4∗ (1 had 2 VOCs) |
| COVID-19 | 1∗ (also had SCA with VOC) | 0 |
| Lung infection | 0 | 1∗ (also had SCA with VOC) |
| Priapism | 1∗ (also had SCA with VOC) | 0 |
| Retinal detachment | 1 | 0 |
| AEs (total 21 AEs in 15 patients) | ||
| 10 AEs in 8 patients | 11 AEs in 7 patients | |
| SCA with VOC | 2 | 2 |
| Chronic sickle cell pain | 1 | 0 |
| General disorder: pain (not otherwise specified) | 0 | 1 |
| Infections and infestations: Other specify: COVID-19 | 1 | 1 |
| CPK increased | 1 | 1∗ (also had COVID-19) |
| Gallbladder pain | 1 | 0 |
| Rash acneiform | 1 | 0 |
| Reproductive system and breast disorders: Penile pain | 1 | 0 |
| Abdominal pain | 1∗ (also had SCA with VOC) | 0 |
| Colitis | 1∗ (also had gallbladder pain) | 0 |
| Bloating | 0 | 1 |
| Headache | 0 | 1∗ (also had bloating) |
| Blurred vision | 0 | 1 |
| Retinopathy | 0 | 1∗ (also had blurred vision and dysmenorrhea) |
| Dysmenorrhea | 0 | 1∗ (also had retinopathy and blurred vision) |
| Diarrhea | 0 | 1 |
| . | SAEs (total 14 SAEs in 10 patients) . | |
|---|---|---|
| IQ (n = 23) . | Placebo (n = 23) . | |
| (8 SAEs in 6 patients) . | (6 SAEs in 4 patients) . | |
| SCA with VOC | 5 | 4∗ (1 had 2 VOCs) |
| COVID-19 | 1∗ (also had SCA with VOC) | 0 |
| Lung infection | 0 | 1∗ (also had SCA with VOC) |
| Priapism | 1∗ (also had SCA with VOC) | 0 |
| Retinal detachment | 1 | 0 |
| AEs (total 21 AEs in 15 patients) | ||
| 10 AEs in 8 patients | 11 AEs in 7 patients | |
| SCA with VOC | 2 | 2 |
| Chronic sickle cell pain | 1 | 0 |
| General disorder: pain (not otherwise specified) | 0 | 1 |
| Infections and infestations: Other specify: COVID-19 | 1 | 1 |
| CPK increased | 1 | 1∗ (also had COVID-19) |
| Gallbladder pain | 1 | 0 |
| Rash acneiform | 1 | 0 |
| Reproductive system and breast disorders: Penile pain | 1 | 0 |
| Abdominal pain | 1∗ (also had SCA with VOC) | 0 |
| Colitis | 1∗ (also had gallbladder pain) | 0 |
| Bloating | 0 | 1 |
| Headache | 0 | 1∗ (also had bloating) |
| Blurred vision | 0 | 1 |
| Retinopathy | 0 | 1∗ (also had blurred vision and dysmenorrhea) |
| Dysmenorrhea | 0 | 1∗ (also had retinopathy and blurred vision) |
| Diarrhea | 0 | 1 |
CPK, creatinine phosphokinase.
Multiple events in a single patient.