Univariate and multivariate analyses for predicting PFS and OS
| . | PFS . | OS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||||||
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | |
| Age ≥80 y | 1.56 | 1.01-2.42 | .042 | - | - | - | 1.82 | 1.09-3.05 | .021 | - | - | - |
| ECOG-PS ≥2 | 1.51 | 0.98-2.33 | .061 | - | - | - | 2.06 | 1.23-3.46 | .006 | - | - | - |
| ISS | 1.63 | 1.18-2.24 | .003 | - | - | - | 1.89 | 1.27-2.8 | .002 | - | - | - |
| ISS III | 1.71 | 1.1-2.64 | .016 | - | - | - | 1.97 | 1.17-3.31 | .01 | - | - | - |
| R-ISS | 2.31 | 1.53-3.51 | <.001 | - | - | - | 2.28 | 1.44-3.62 | <.001 | - | - | - |
| R-ISS III | 2.04 | 1.19-3.47 | .009 | 2.8 | 1.58-4.98 | <.001 | 1.88 | 1.04-3.38 | .035 | 2.21 | 1.19-4.08 | .011 |
| High risk cytogenetics | 1.78 | 1.06-3 | .029 | - | - | - | 1.14 | 0.62-2.12 | .663 | - | - | - |
| High CTCs | 2.12 | 1.37-3.28 | .001 | 1.86 | 1.19-2.9 | .006 | 2.35 | 1.4-3.95 | .001 | 2.05 | 1.22-3.46 | .007 |
| Positive CTCs | 1.92 | 1.02-3.64 | .043 | - | - | - | 1.23 | 0.6-2.51 | .556 | - | - | - |
| High TLG | 1.65 | 1.04-2.62 | .03 | 1.78 | 1.12-2.83 | .015 | 1.91 | 1.13-3.22 | .015 | 2.03 | 1.2-3.45 | .008 |
| Number of FLs >3 | 1.21 | 0.77-1.89 | .394 | - | - | - | 1.49 | 0.87-2.56 | .142 | - | - | - |
| SUVmax >4.2 | 1.34 | 0.87-2.07 | .177 | - | - | - | 1.36 | 0.81-2.26 | .235 | - | - | - |
| EMD | 0.94 | 0.34-2.59 | .916 | - | - | - | 1.61 | 0.58-4.45 | .357 | - | - | - |
| CR achievement | 0.37 | 0.23-0.58 | <.001 | 0.32 | 0.2-0.52 | <.001 | 0.43 | 0.25-0.73 | .002 | 0.4 | 0.23-0.69 | .001 |
| . | PFS . | OS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate analysis . | Univariate analysis . | Multivariate analysis . | |||||||||
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | |
| Age ≥80 y | 1.56 | 1.01-2.42 | .042 | - | - | - | 1.82 | 1.09-3.05 | .021 | - | - | - |
| ECOG-PS ≥2 | 1.51 | 0.98-2.33 | .061 | - | - | - | 2.06 | 1.23-3.46 | .006 | - | - | - |
| ISS | 1.63 | 1.18-2.24 | .003 | - | - | - | 1.89 | 1.27-2.8 | .002 | - | - | - |
| ISS III | 1.71 | 1.1-2.64 | .016 | - | - | - | 1.97 | 1.17-3.31 | .01 | - | - | - |
| R-ISS | 2.31 | 1.53-3.51 | <.001 | - | - | - | 2.28 | 1.44-3.62 | <.001 | - | - | - |
| R-ISS III | 2.04 | 1.19-3.47 | .009 | 2.8 | 1.58-4.98 | <.001 | 1.88 | 1.04-3.38 | .035 | 2.21 | 1.19-4.08 | .011 |
| High risk cytogenetics | 1.78 | 1.06-3 | .029 | - | - | - | 1.14 | 0.62-2.12 | .663 | - | - | - |
| High CTCs | 2.12 | 1.37-3.28 | .001 | 1.86 | 1.19-2.9 | .006 | 2.35 | 1.4-3.95 | .001 | 2.05 | 1.22-3.46 | .007 |
| Positive CTCs | 1.92 | 1.02-3.64 | .043 | - | - | - | 1.23 | 0.6-2.51 | .556 | - | - | - |
| High TLG | 1.65 | 1.04-2.62 | .03 | 1.78 | 1.12-2.83 | .015 | 1.91 | 1.13-3.22 | .015 | 2.03 | 1.2-3.45 | .008 |
| Number of FLs >3 | 1.21 | 0.77-1.89 | .394 | - | - | - | 1.49 | 0.87-2.56 | .142 | - | - | - |
| SUVmax >4.2 | 1.34 | 0.87-2.07 | .177 | - | - | - | 1.36 | 0.81-2.26 | .235 | - | - | - |
| EMD | 0.94 | 0.34-2.59 | .916 | - | - | - | 1.61 | 0.58-4.45 | .357 | - | - | - |
| CR achievement | 0.37 | 0.23-0.58 | <.001 | 0.32 | 0.2-0.52 | <.001 | 0.43 | 0.25-0.73 | .002 | 0.4 | 0.23-0.69 | .001 |