Table 1.

Key frailty scores

IMWG5 Revised Myeloma Comorbidity Index22 UK Myeloma Research Alliance Myeloma Risk Profile31 Mayo risk score24 IFM simplified frailty25 
No. of patients 869 NR 2372 351 1618 
Frail patients, % 30 NR 35 21 49 
OS in frail patients 57% at 3 y NR mOS 20-25 mo mOS 28 mo mOS 42 mo 
No. of groups 
Parameters Age, CCI, activities of daily living, independent activities of daily living Estimated glomerular filtration rate, pulmonary function tests, frailty, age, cytogenetics, PS Age, Revised International Staging System, C-reactive protein, PS Age, N-terminal probrain natriuretic peptide, ECOG Age, CCI, ECOG 
Population CT CT, RW CT RW CT 
IMWG5 Revised Myeloma Comorbidity Index22 UK Myeloma Research Alliance Myeloma Risk Profile31 Mayo risk score24 IFM simplified frailty25 
No. of patients 869 NR 2372 351 1618 
Frail patients, % 30 NR 35 21 49 
OS in frail patients 57% at 3 y NR mOS 20-25 mo mOS 28 mo mOS 42 mo 
No. of groups 
Parameters Age, CCI, activities of daily living, independent activities of daily living Estimated glomerular filtration rate, pulmonary function tests, frailty, age, cytogenetics, PS Age, Revised International Staging System, C-reactive protein, PS Age, N-terminal probrain natriuretic peptide, ECOG Age, CCI, ECOG 
Population CT CT, RW CT RW CT 

CT, clinical trial; mOS, median overall survival; NR, not reported; RW, real world.

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