Multivariable regression of determinants of ABR and AJBR during ITI
| . | Parameter . | HR . | Lower CI . | Upper CI . | P value . |
|---|---|---|---|---|---|
| ABR | Peak titer ≥200 BU | 2.434 | 1.726 | 3.434 | < .001 |
| Peak titer of 40-199 BU | 2.662 | 1.788 | 3.965 | < .001 | |
| Peak titer of 6-39 BU (reference) | 1 | — | — | — | |
| ITI + aPCC prophylaxis | 0.678 | 0.354 | 1.298 | .24 | |
| ITI + rFVIIa prophylaxis | 1.63 | 0.986 | 2.694 | .057 | |
| ITI (reference) | 1 | — | — | — | |
| Daily ITI infusions | 0.448 | 0.326 | 0.616 | < .001 | |
| Nondaily ITI infusions (reference) | 1 | — | — | — | |
| ITI dose ≥95 IU/kg per day | 0.938 | 0.651 | 1.352 | .731 | |
| ITI dose <95 IU/kg per day (reference) | 1 | — | — | — | |
| AJBR | Peak titer ≥200 BU | 4.895 | 3.224 | 7.431 | < .001 |
| Peak titer of 40-199 BU | 2.952 | 1.859 | 4.689 | < .001 | |
| Peak titer of 6-39 BU [reference] | 1 | — | — | — | |
| ITI + aPCC prophylaxis | 0.374 | 0.181 | 0.774 | .008 | |
| ITI + rFVIIa prophylaxis | 1.455 | 0.836 | 2.534 | .184 | |
| ITI (reference) | 1 | — | — | — | |
| Daily ITI infusions | 0.439 | 0.308 | 0.627 | < .001 | |
| Nondaily ITI infusions (reference) | 1 | — | — | — | |
| ITI dose ≥95 IU/kg per day | 1.144 | 0.744 | 1.761 | .54 | |
| ITI dose <95 IU/kg per day (reference) | 1 | — | — | — |
| . | Parameter . | HR . | Lower CI . | Upper CI . | P value . |
|---|---|---|---|---|---|
| ABR | Peak titer ≥200 BU | 2.434 | 1.726 | 3.434 | < .001 |
| Peak titer of 40-199 BU | 2.662 | 1.788 | 3.965 | < .001 | |
| Peak titer of 6-39 BU (reference) | 1 | — | — | — | |
| ITI + aPCC prophylaxis | 0.678 | 0.354 | 1.298 | .24 | |
| ITI + rFVIIa prophylaxis | 1.63 | 0.986 | 2.694 | .057 | |
| ITI (reference) | 1 | — | — | — | |
| Daily ITI infusions | 0.448 | 0.326 | 0.616 | < .001 | |
| Nondaily ITI infusions (reference) | 1 | — | — | — | |
| ITI dose ≥95 IU/kg per day | 0.938 | 0.651 | 1.352 | .731 | |
| ITI dose <95 IU/kg per day (reference) | 1 | — | — | — | |
| AJBR | Peak titer ≥200 BU | 4.895 | 3.224 | 7.431 | < .001 |
| Peak titer of 40-199 BU | 2.952 | 1.859 | 4.689 | < .001 | |
| Peak titer of 6-39 BU [reference] | 1 | — | — | — | |
| ITI + aPCC prophylaxis | 0.374 | 0.181 | 0.774 | .008 | |
| ITI + rFVIIa prophylaxis | 1.455 | 0.836 | 2.534 | .184 | |
| ITI (reference) | 1 | — | — | — | |
| Daily ITI infusions | 0.439 | 0.308 | 0.627 | < .001 | |
| Nondaily ITI infusions (reference) | 1 | — | — | — | |
| ITI dose ≥95 IU/kg per day | 1.144 | 0.744 | 1.761 | .54 | |
| ITI dose <95 IU/kg per day (reference) | 1 | — | — | — |
Example of interpretation: in the multivariable analysis adjusted for all parameters shown, patients with a peak inhibitor titer of ≥200 BU had a 2.4 times higher ABR and a 4.9 times higher AJBR than those with a titer of 6 to 39 BU; thus, the titers were an independent determinant of bleeding rates.