Table 2. Thrombin generation with... | American Society of Hematology

Table 2.

Thrombin generation with addition of 450 nM PS antibody according to the severity of the disease

Patient	Control, nM	+PS Ab, nM	Total increase, nM
Group A (severe, on EHL product)
1	349	670	321
2	243	397	154
8	324	390	66
9	342	425	83
10	284	474	190
Average	308.4	471.2	162.8
Group B (severe, on SHL product)
6	226	385	159
Group C (moderate)
11∗	492	507	15
Group D (mild)
3	367	470	103
4	402	454	52
5	339	422	83
7	517	665	148
Average	406	503	97

Patient	Control, nM	+PS Ab, nM	Total increase, nM
Group A (severe, on EHL product)
1	349	670	321
2	243	397	154
8	324	390	66
9	342	425	83
10	284	474	190
Average	308.4	471.2	162.8
Group B (severe, on SHL product)
6	226	385	159
Group C (moderate)
11∗	492	507	15
Group D (mild)
3	367	470	103
4	402	454	52
5	339	422	83
7	517	665	148
Average	406	503	97

∗

The single patient with moderate FIX deficiency had an unusually high baseline peak thrombin level. The addition of PS antibody produced a 15-nM increase in thrombin generation.

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