| Age groups | |
| Neonates | PK and PD in gestational age <37 wk Safety in the presence of comorbidities Critically ill or on mechanical ventilation Absorption with naso-jejunum tube feeding Presence of arterial central lines Sepsis
Access to liquid formulation or sprinkles Management surrounding invasive procedures and surgeries Impact on growth and development, immune function, and bone health
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| Toddler/young child | Availability of a liquid formulation or pellets Safety with noncontact activities; eg, in school or on the playground
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| Teenager | Safety for athletes playing contact sports Management of menstrual bleeding (in young women) Impact on quality of life Safety in the presence of high-risk behavior Optimal contraceptive options Safety with use of concomitant antifibrinolytics
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| Medical comorbidities | |
| Cancer | Safety with chemotherapy induced toxicity affecting different organ systems, for example, liver, kidney, and GI, thrombocytopenia, concomitant medications, and sepsis Periprocedural management
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| Renal/liver dysfunction, GI malabsorption, or short gut | Use in mild or moderate renal and liver dysfunction PK/PD in GI malabsorption and short gut Key safety considerations
|