Characteristics of all individuals with genetically defined ADAN
| . | All n = 90 . | Clinically characterized n = 66 . | Positive results for neutrophil autoantibodies n = 14 . |
|---|---|---|---|
| Age, y, median (and range) | 42 (18-93) | 41 (18-93) | 34 (21-63) |
| Sex, females/males (%) | 69/31 | 67/33 | 64/36 |
| ANC follow-up, y, median (range) | — | 4 (1-20) | N/A |
| Antibiotic follow-up, y, median (range) | — | 7 (2-11) | N/A |
| Number of ANC analyses per subject, median, (range) | — | 4 (1-33) | N/A |
| ANC mean (SD) | — | 1.0 (0.29)∗ | 1.0 (0.29) |
| . | All n = 90 . | Clinically characterized n = 66 . | Positive results for neutrophil autoantibodies n = 14 . |
|---|---|---|---|
| Age, y, median (and range) | 42 (18-93) | 41 (18-93) | 34 (21-63) |
| Sex, females/males (%) | 69/31 | 67/33 | 64/36 |
| ANC follow-up, y, median (range) | — | 4 (1-20) | N/A |
| Antibiotic follow-up, y, median (range) | — | 7 (2-11) | N/A |
| Number of ANC analyses per subject, median, (range) | — | 4 (1-33) | N/A |
| ANC mean (SD) | — | 1.0 (0.29)∗ | 1.0 (0.29) |
All were included (n = 90), 66 were also clinically characterized, and 14 tested positive for neutrophil autoantibodies (GAT, GIFT, and MAIGA).
N/A, not applicable; SD, standard deviation.
In the subgroup with negative results for anti-neutrophil autoantibodies, the mean ANC was 1.0 × 109/L (SD, 0.37 × 109/L); when compared with the subgroup with detected autoantibodies, no statistically significant difference was noted (P > .05).