Characteristics of descriptive and cohort studies in pregnant patients with β TM and β TI
| Author (year) . | Single vs multicenter . | Design . | Years of study . | Inclusion criteria . |
|---|---|---|---|---|
| Case-Series | ||||
| Aessopos (1999) | Single | Descriptive study with no comparator | 1989-1999 | TM: pregnant women with a 10-y history of intensive treatment and hyper transfusion, on DFO iron chelation 5 d/wk before pregnancy. TI: pregnant women with no major bone deformities and Hb >70 g/L. |
| Bajoria (2009) | Single | Descriptive study with no comparator | 1994-2009 | Pregnant women with β TM with hypogonadotropic hypogonadism |
| Cassinerio (2017) | Multi | Descriptive study with no comparator | 2007- 2016 | Pregnant women with β TM |
| Daskalakis (1998) | Single | Descriptive study with no comparator | 1993-1996 | Pregnant women with β TM |
| Diamantidis (2016) | Single | Descriptive study with no comparator | 2008-2013 | Pregnant women with β TM who received deferasirox in early pregnancy |
| Fozza (2017) | Single | Descriptive study with no comparator | 2001-2017 | Pregnant women with β TM |
| Karagiorga-Lagana (1998) | Single | Descriptive study with no comparator | 1983-1997 | Pregnant women with TM and TI |
| Nassar (2008) | Multi | Descriptive study with no comparator | Not reported | Pregnant women with TI |
| Origa (2010) | Multi | Descriptive study with no comparator | 1997-2008 | Women with β TM and β TI |
| Roumi (2017) | Multi | Descriptive study with no comparator | Not reported | Pregnant women with TI |
| Toumba (2008) | Multi | Descriptive study with no comparator | 1990-2004 | All women with thalassemia who were followed since their birth and who conceived, with treatment or spontaneously, and had successful deliveries |
| Tuck (2005) | Single | Descriptive study with no comparator | 1989-2004 | Pregnant women with β TM |
| Vlachodimitropoulou (2018) | Single | Descriptive study with no comparator | 2009-2015 | Women with β TM and β TI |
| Voskaridou (2014) | Single | Descriptive study with no comparator | Not reported | Pregnant women with TI |
| Cohort Studies | ||||
| Luewan (2009) | Single | Cohort study | Not reported | Singleton pregnancies Cases: β/HbE TM. Controls: matched low risk pregnancies (2:1 ratio) |
| Author (year) . | Single vs multicenter . | Design . | Years of study . | Inclusion criteria . |
|---|---|---|---|---|
| Case-Series | ||||
| Aessopos (1999) | Single | Descriptive study with no comparator | 1989-1999 | TM: pregnant women with a 10-y history of intensive treatment and hyper transfusion, on DFO iron chelation 5 d/wk before pregnancy. TI: pregnant women with no major bone deformities and Hb >70 g/L. |
| Bajoria (2009) | Single | Descriptive study with no comparator | 1994-2009 | Pregnant women with β TM with hypogonadotropic hypogonadism |
| Cassinerio (2017) | Multi | Descriptive study with no comparator | 2007- 2016 | Pregnant women with β TM |
| Daskalakis (1998) | Single | Descriptive study with no comparator | 1993-1996 | Pregnant women with β TM |
| Diamantidis (2016) | Single | Descriptive study with no comparator | 2008-2013 | Pregnant women with β TM who received deferasirox in early pregnancy |
| Fozza (2017) | Single | Descriptive study with no comparator | 2001-2017 | Pregnant women with β TM |
| Karagiorga-Lagana (1998) | Single | Descriptive study with no comparator | 1983-1997 | Pregnant women with TM and TI |
| Nassar (2008) | Multi | Descriptive study with no comparator | Not reported | Pregnant women with TI |
| Origa (2010) | Multi | Descriptive study with no comparator | 1997-2008 | Women with β TM and β TI |
| Roumi (2017) | Multi | Descriptive study with no comparator | Not reported | Pregnant women with TI |
| Toumba (2008) | Multi | Descriptive study with no comparator | 1990-2004 | All women with thalassemia who were followed since their birth and who conceived, with treatment or spontaneously, and had successful deliveries |
| Tuck (2005) | Single | Descriptive study with no comparator | 1989-2004 | Pregnant women with β TM |
| Vlachodimitropoulou (2018) | Single | Descriptive study with no comparator | 2009-2015 | Women with β TM and β TI |
| Voskaridou (2014) | Single | Descriptive study with no comparator | Not reported | Pregnant women with TI |
| Cohort Studies | ||||
| Luewan (2009) | Single | Cohort study | Not reported | Singleton pregnancies Cases: β/HbE TM. Controls: matched low risk pregnancies (2:1 ratio) |
Hb, hemoglobin; HbE, hemoglobin E.