Grade 2 or higher adverse events associated with ibrutinib and venetoclax therapies
| Adverse event . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| Alanine aminotransferase increase | 1 | |||
| Anemia | 1 | |||
| Anorexia | 1 | |||
| Arthralgia | 5 | 1 | ||
| Atrial fibrillation | 1 | 2 | ||
| Bruising | 2 | |||
| Diarrhea | 11 | 3 | ||
| Fatigue | 2 | 1 | ||
| Gastroesophageal reflux disease | 12 | |||
| Headache | 1 | |||
| Hematoma | 1 | |||
| Hematuria | 1 | |||
| Hyperphosphatemia | 8 | |||
| Hypertension | 2 | 1 | ||
| Hyponatremia | 1 | |||
| Intracranial hemorrhage | 1 | |||
| Lung infection | 2 | |||
| Malaise | 1 | |||
| Mucositis | 9 | 4 | ||
| Myalgia | 3 | |||
| Nausea | 5 | |||
| Neutropenia | 2 | 13 | 4 | |
| Platelet decrease | 1 | |||
| Skin rash | 5 | |||
| Soft tissue infection | 2 | 1 | ||
| Tumor lysis syndrome | 3 | |||
| Upper respiratory infection | 4 | |||
| Urinary tract infection | 5 | |||
| Ventricular arrhythmia | 1 | 1 | 2 |
| Adverse event . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| Alanine aminotransferase increase | 1 | |||
| Anemia | 1 | |||
| Anorexia | 1 | |||
| Arthralgia | 5 | 1 | ||
| Atrial fibrillation | 1 | 2 | ||
| Bruising | 2 | |||
| Diarrhea | 11 | 3 | ||
| Fatigue | 2 | 1 | ||
| Gastroesophageal reflux disease | 12 | |||
| Headache | 1 | |||
| Hematoma | 1 | |||
| Hematuria | 1 | |||
| Hyperphosphatemia | 8 | |||
| Hypertension | 2 | 1 | ||
| Hyponatremia | 1 | |||
| Intracranial hemorrhage | 1 | |||
| Lung infection | 2 | |||
| Malaise | 1 | |||
| Mucositis | 9 | 4 | ||
| Myalgia | 3 | |||
| Nausea | 5 | |||
| Neutropenia | 2 | 13 | 4 | |
| Platelet decrease | 1 | |||
| Skin rash | 5 | |||
| Soft tissue infection | 2 | 1 | ||
| Tumor lysis syndrome | 3 | |||
| Upper respiratory infection | 4 | |||
| Urinary tract infection | 5 | |||
| Ventricular arrhythmia | 1 | 1 | 2 |