Additional characteristics at PICU admission (n = 1067)
| Characteristic . | N (%) . |
|---|---|
| ICU-related | |
| PICU size, groups created based on total number of admissions | |
| Tertile 1 (>14 HCT-PICU admissions) | 821 (77) |
| Tertile 2 (5-14 HCT-PICU admissions) | 175 (17) |
| Tertile 3 (<5 HCT-PICU admissions) | 72 (7) |
| Number of ICU admissions per patient | |
| 1 | 597 (56) |
| 2 | 248 (23) |
| 3+ | 222 (21) |
| Age at first PICU admission (y)∗ | |
| 0 to <1 | 98 (9) |
| 1-4 | 259 (24) |
| 5-12 | 365 (34) |
| 13-21 | 344 (32) |
| BMI status at PICU admission† | |
| Underweight | 90 (8) |
| Normal | 497 (47) |
| Overweight (adult only) | 10 (1) |
| Obese | 114 (11) |
| Missing | 356 (33) |
| PRISM-3 score (median, IQR) | 9 (4-14) |
| Critical care therapies in first ICU admission | |
| IMV | 395 (37) |
| Noninvasive mechanical ventilation | 175 (16) |
| RRT | 126 (12) |
| Infections in first ICU admission | |
| Gram-positive infection | 115 (11) |
| Gram-negative infection | 87 (8) |
| Fungal infection | 94 (9) |
| Viral infection | 273 (25) |
| Sepsis, Severe Sepsis, or Septic Shock | 256 (24) |
| Transplant-related | |
| Time from HCT to first ICU admission (mo), median (min-max) | 3 (0-70) |
| Neutrophil recovery relationship to first ICU admission∗ | |
| Neutrophil engrafted before first ICU admission | 761 (71) |
| Neutrophil engrafted after first ICU admission and before first ICU discharge | 89 (8) |
| Neutrophil engrafted after ICU discharge | 122 (11) |
| Never achieved neutrophil engraftment | 77 (7) |
| aGVHD relationship to first ICU admission∗,‡ | |
| No aGVHD | 299 (65) |
| aGVHD before first ICU admission | 124 (27) |
| Grade 1-2 | 53 (11) |
| Grade 3-4 | 69 (15) |
| aGVHD after first ICU admission and before first ICU discharge | 12 (3) |
| Grade 1-2 | 3 (0) |
| Grade 3-4 | 9 (2) |
| aGVHD after first ICU discharge | 27 (6) |
| Grade 1-2 | 11 (2) |
| Grade 3-4 | 16 (4) |
| cGVHD relationship to first ICU admission∗ | |
| No cGVHD | 748 (70) |
| cGVHD before first ICU admission | 130 (12) |
| Limited | 33 (3) |
| Extensive | 94 (9) |
| cGVHD after first ICU admission | 163 (15) |
| Limited | 43 (4) |
| Extensive | 119 (11) |
| Malignancy relapse before first ICU visit | 103 (10) |
| Characteristic . | N (%) . |
|---|---|
| ICU-related | |
| PICU size, groups created based on total number of admissions | |
| Tertile 1 (>14 HCT-PICU admissions) | 821 (77) |
| Tertile 2 (5-14 HCT-PICU admissions) | 175 (17) |
| Tertile 3 (<5 HCT-PICU admissions) | 72 (7) |
| Number of ICU admissions per patient | |
| 1 | 597 (56) |
| 2 | 248 (23) |
| 3+ | 222 (21) |
| Age at first PICU admission (y)∗ | |
| 0 to <1 | 98 (9) |
| 1-4 | 259 (24) |
| 5-12 | 365 (34) |
| 13-21 | 344 (32) |
| BMI status at PICU admission† | |
| Underweight | 90 (8) |
| Normal | 497 (47) |
| Overweight (adult only) | 10 (1) |
| Obese | 114 (11) |
| Missing | 356 (33) |
| PRISM-3 score (median, IQR) | 9 (4-14) |
| Critical care therapies in first ICU admission | |
| IMV | 395 (37) |
| Noninvasive mechanical ventilation | 175 (16) |
| RRT | 126 (12) |
| Infections in first ICU admission | |
| Gram-positive infection | 115 (11) |
| Gram-negative infection | 87 (8) |
| Fungal infection | 94 (9) |
| Viral infection | 273 (25) |
| Sepsis, Severe Sepsis, or Septic Shock | 256 (24) |
| Transplant-related | |
| Time from HCT to first ICU admission (mo), median (min-max) | 3 (0-70) |
| Neutrophil recovery relationship to first ICU admission∗ | |
| Neutrophil engrafted before first ICU admission | 761 (71) |
| Neutrophil engrafted after first ICU admission and before first ICU discharge | 89 (8) |
| Neutrophil engrafted after ICU discharge | 122 (11) |
| Never achieved neutrophil engraftment | 77 (7) |
| aGVHD relationship to first ICU admission∗,‡ | |
| No aGVHD | 299 (65) |
| aGVHD before first ICU admission | 124 (27) |
| Grade 1-2 | 53 (11) |
| Grade 3-4 | 69 (15) |
| aGVHD after first ICU admission and before first ICU discharge | 12 (3) |
| Grade 1-2 | 3 (0) |
| Grade 3-4 | 9 (2) |
| aGVHD after first ICU discharge | 27 (6) |
| Grade 1-2 | 11 (2) |
| Grade 3-4 | 16 (4) |
| cGVHD relationship to first ICU admission∗ | |
| No cGVHD | 748 (70) |
| cGVHD before first ICU admission | 130 (12) |
| Limited | 33 (3) |
| Extensive | 94 (9) |
| cGVHD after first ICU admission | 163 (15) |
| Limited | 43 (4) |
| Extensive | 119 (11) |
| Malignancy relapse before first ICU visit | 103 (10) |
Additional characteristics at time of PICU admission.
BMI, body mass index; PRISM-3; Pediatric Risk of Mortality Score.
Variables with minimal missing data are noted as follows: age at first PICU admission n = 1 (0%); neutrophil recovery relationship to first PICU admission n = 18 (2%); aGVHD grade unknown n = 2 (0%); cGVHD relationship to first PICU admission, missing n = 26 (2%), cGVHD grade unknown n = 4 (0%).
Children (aged from 2 to <20), BMI is adjusted by sex and age (mo) according to Centers for Disease Control and Prevention smoothed growth charts with percentile cutoffs as follows: underweight (<5%), normal weight (5%-84.9%), overweight (85%-94.9%), and obese (≥95%). Adults aged ≥20 years, BMI is interpreted using standard weight status categories as follows: underweight (<18.5), normal weight (18.5-24.9), overweight (25.0-29.9), and obese (≥30.0). These categories are the same for men and women of all body types and ages.
Variables with significant missing data are noted as follows: aGVHD relationship to first PICU admission, missing or not collected n = 605 (56%).