Treatment emergent nonhematologic adverse events occurring in at least 10% of patients and all grade 3 or higher events
| Adverse events . | Grade 1-2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| Abdominal distension | 3 (14) | 0 | 0 | 0 |
| Abdominal pain | 6 (27) | 0 | 0 | 0 |
| ALT increased | 2 (9) | 2 (9) | 0 | 0 |
| Anorexia | 8 (36) | 0 | 0 | 0 |
| Anxiety | 5 (23) | 0 | 0 | 0 |
| Arthralgia | 6 (27) | 0 | 0 | 0 |
| Bone pain | 2 (9) | 1 (5) | 0 | 0 |
| Bruising | 5 (23) | 0 | 0 | 0 |
| Chills | 4 (18) | 1 (5) | 0 | 0 |
| Constipation | 8 (36) | 2 (9) | 0 | 0 |
| Cough | 3 (14) | 1 (5) | 0 | 0 |
| Depression | 3 (14) | 0 | 0 | 0 |
| Diarrhea | 3 (14) | 2 (9) | 0 | 0 |
| Dizziness | 5 (23) | 0 | 0 | 0 |
| Dysphagia | 3 (14) | 0 | 0 | 0 |
| Epistaxis | 2 (9) | 1 (5) | 0 | 0 |
| Fatigue | 2 (9) | 2 (9) | 0 | 0 |
| Febrile neutropenia | 0 | 4 (18) | 0 | 0 |
| Hyperbilirubinemia | 3 (14) | 1 (5) | 1 (5) | 0 |
| Hyperkalemia | 2 (9) | 1 (5) | 0 | 0 |
| Hyponatremia | 0 | 1 (5) | 0 | 0 |
| Infection | 2 (9) | 13 (59) | 2 (9) | 2 (9) |
| Insomnia | 4 (18) | 0 | 0 | 0 |
| Mucositis oral | 1 (5) | 2 (9) | 0 | 0 |
| Myalgia/muscle weakness | 5 (23) | 1 (5) | 0 | 0 |
| Sepsis | 0 | 1 (5) | 0 | 0 |
| Thromboembolic event | 0 | 1 (5) | 0 | 0 |
| Tumor lysis syndrome | 0 | 1 (5) | 0 | 0 |
| Adverse events . | Grade 1-2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| Abdominal distension | 3 (14) | 0 | 0 | 0 |
| Abdominal pain | 6 (27) | 0 | 0 | 0 |
| ALT increased | 2 (9) | 2 (9) | 0 | 0 |
| Anorexia | 8 (36) | 0 | 0 | 0 |
| Anxiety | 5 (23) | 0 | 0 | 0 |
| Arthralgia | 6 (27) | 0 | 0 | 0 |
| Bone pain | 2 (9) | 1 (5) | 0 | 0 |
| Bruising | 5 (23) | 0 | 0 | 0 |
| Chills | 4 (18) | 1 (5) | 0 | 0 |
| Constipation | 8 (36) | 2 (9) | 0 | 0 |
| Cough | 3 (14) | 1 (5) | 0 | 0 |
| Depression | 3 (14) | 0 | 0 | 0 |
| Diarrhea | 3 (14) | 2 (9) | 0 | 0 |
| Dizziness | 5 (23) | 0 | 0 | 0 |
| Dysphagia | 3 (14) | 0 | 0 | 0 |
| Epistaxis | 2 (9) | 1 (5) | 0 | 0 |
| Fatigue | 2 (9) | 2 (9) | 0 | 0 |
| Febrile neutropenia | 0 | 4 (18) | 0 | 0 |
| Hyperbilirubinemia | 3 (14) | 1 (5) | 1 (5) | 0 |
| Hyperkalemia | 2 (9) | 1 (5) | 0 | 0 |
| Hyponatremia | 0 | 1 (5) | 0 | 0 |
| Infection | 2 (9) | 13 (59) | 2 (9) | 2 (9) |
| Insomnia | 4 (18) | 0 | 0 | 0 |
| Mucositis oral | 1 (5) | 2 (9) | 0 | 0 |
| Myalgia/muscle weakness | 5 (23) | 1 (5) | 0 | 0 |
| Sepsis | 0 | 1 (5) | 0 | 0 |
| Thromboembolic event | 0 | 1 (5) | 0 | 0 |
| Tumor lysis syndrome | 0 | 1 (5) | 0 | 0 |