Vector shedding in body fluids
| Parameter . | Cohort 1 (n = 2) . | Cohort 2 (n = 2) . | Cohort 3 (n = 2) . | Cohort 4 (n = 5) . | Total (N = 11) . |
|---|---|---|---|---|---|
| Plasma | n = 2 | n = 2 | n = 2 | n = 5 | n = 11 |
| Peak value, vg/mL | 2.6 × 107 (2.7 × 107) | 2.9 × 108 (3.8 × 108) | 1.8 × 109 (1.4 × 109) | 3.4 × 109 (2.8 × 109) | 2.0 × 109 (2.4 × 109) |
| Days to peak value | 1.5 (0.7) | 1.0 (0.0) | 1.0 (0.0) | 1.4 (0.6) | 1.3 (0.5) |
| Days to first of 3 consecutive negative results | 22.0 (8.5) (n = 2) | 15.0 (0.0) (n = 2) | 56.5 (0.7) (n = 2) | 84.7 (47.9) (n = 3) | 49.0 (39.3) (n = 9) |
| Saliva | n = 2 | n = 2 | n = 2 | n = 5 | n = 11 |
| Peak value, vg/mL | 4.5 × 104 (2.2 × 104) | 1.6 × 105 (9.0 × 104) | 1.6 × 106 (4.2 × 105) | 7.0 × 106 (5.2 × 106) | 3.5 × 106 (4.7 × 106) |
| Days to peak value | 11.5 (5.0) | 7.5 (0.7) | 12.0 (4.2) | 11.8 (4.0) | 11.0 (3.7) |
| Days to first of 3 consecutive negative results | 29.0 (-) (n = 1) | 29.0 (0.0) (n = 2) | 57.0 (-) (n = 1) | 60.5 (17.6) (n = 4) | 48.3 (19.7) (n = 8) |
| Semen | n = 1 | n = 1 | n = 2 | n = 5 | n = 9 |
| Peak value, vg/mL | 1.5 × 104 (-) | 3.7 × 104 (-) | 1.5 × 105 (5.0 × 103) | 10.0 × 104 (1.5 × 105) | 9.3 × 104 (1.2 × 105) |
| Days to peak value | 8.0 (-) | 15.0 (-) | 11.0 (4.2) | 14.4 (9.0) | 13.0 (7.0) |
| Days to first negative result | 18.0 (14.1) (n = 2) | 15.0 (-) (n = 1) | 42.0 (18.4) (n = 2) | 42.2 (27.5) (n = 5) | 34.6 (23.3) (n = 10) |
| Stool | n = 2 | n = 0 | n = 2 | n = 5 | n = 9 |
| Peak value, vg/mL | 6.0 × 102 (4.1 × 102) | — | 2.5 × 103 (2.5 × 103) | 2.3 × 103 (2.8 × 103) | 2.0 × 103 (2.3 × 103) |
| Days to peak value | 8.0 (0.0) | — | 7.5 (0.7) | 17.0 (10.3) | 12.9 (8.8) |
| Days to first negative result | 15.0 (-) (n = 1) | 15.0 (-) (n = 1) | 42.0 (18.4) (n = 2) | 72.6 (62.1) (n = 5) | 53.0 (51.0) (n = 9) |
| Urine | n = 0 | n = 0 | n = 0 | n = 3 | n = 3 |
| Peak value, vg/mL | — | — | — | 9.7 × 103 (6.2 × 103) | 9.7 × 103 (6.2 × 103) |
| Days to peak value | — | — | — | 9.7 (3.8) | 9.7 (3.8) |
| Days to first negative result | 8.0 (0.0) (n = 2) | 7.5 (0.7) (n = 2) | 8.5 (0.7) (n = 2) | 14.8 (8.2) (n = 5) | 11.1 (6.3) (n = 11) |
| Parameter . | Cohort 1 (n = 2) . | Cohort 2 (n = 2) . | Cohort 3 (n = 2) . | Cohort 4 (n = 5) . | Total (N = 11) . |
|---|---|---|---|---|---|
| Plasma | n = 2 | n = 2 | n = 2 | n = 5 | n = 11 |
| Peak value, vg/mL | 2.6 × 107 (2.7 × 107) | 2.9 × 108 (3.8 × 108) | 1.8 × 109 (1.4 × 109) | 3.4 × 109 (2.8 × 109) | 2.0 × 109 (2.4 × 109) |
| Days to peak value | 1.5 (0.7) | 1.0 (0.0) | 1.0 (0.0) | 1.4 (0.6) | 1.3 (0.5) |
| Days to first of 3 consecutive negative results | 22.0 (8.5) (n = 2) | 15.0 (0.0) (n = 2) | 56.5 (0.7) (n = 2) | 84.7 (47.9) (n = 3) | 49.0 (39.3) (n = 9) |
| Saliva | n = 2 | n = 2 | n = 2 | n = 5 | n = 11 |
| Peak value, vg/mL | 4.5 × 104 (2.2 × 104) | 1.6 × 105 (9.0 × 104) | 1.6 × 106 (4.2 × 105) | 7.0 × 106 (5.2 × 106) | 3.5 × 106 (4.7 × 106) |
| Days to peak value | 11.5 (5.0) | 7.5 (0.7) | 12.0 (4.2) | 11.8 (4.0) | 11.0 (3.7) |
| Days to first of 3 consecutive negative results | 29.0 (-) (n = 1) | 29.0 (0.0) (n = 2) | 57.0 (-) (n = 1) | 60.5 (17.6) (n = 4) | 48.3 (19.7) (n = 8) |
| Semen | n = 1 | n = 1 | n = 2 | n = 5 | n = 9 |
| Peak value, vg/mL | 1.5 × 104 (-) | 3.7 × 104 (-) | 1.5 × 105 (5.0 × 103) | 10.0 × 104 (1.5 × 105) | 9.3 × 104 (1.2 × 105) |
| Days to peak value | 8.0 (-) | 15.0 (-) | 11.0 (4.2) | 14.4 (9.0) | 13.0 (7.0) |
| Days to first negative result | 18.0 (14.1) (n = 2) | 15.0 (-) (n = 1) | 42.0 (18.4) (n = 2) | 42.2 (27.5) (n = 5) | 34.6 (23.3) (n = 10) |
| Stool | n = 2 | n = 0 | n = 2 | n = 5 | n = 9 |
| Peak value, vg/mL | 6.0 × 102 (4.1 × 102) | — | 2.5 × 103 (2.5 × 103) | 2.3 × 103 (2.8 × 103) | 2.0 × 103 (2.3 × 103) |
| Days to peak value | 8.0 (0.0) | — | 7.5 (0.7) | 17.0 (10.3) | 12.9 (8.8) |
| Days to first negative result | 15.0 (-) (n = 1) | 15.0 (-) (n = 1) | 42.0 (18.4) (n = 2) | 72.6 (62.1) (n = 5) | 53.0 (51.0) (n = 9) |
| Urine | n = 0 | n = 0 | n = 0 | n = 3 | n = 3 |
| Peak value, vg/mL | — | — | — | 9.7 × 103 (6.2 × 103) | 9.7 × 103 (6.2 × 103) |
| Days to peak value | — | — | — | 9.7 (3.8) | 9.7 (3.8) |
| Days to first negative result | 8.0 (0.0) (n = 2) | 7.5 (0.7) (n = 2) | 8.5 (0.7) (n = 2) | 14.8 (8.2) (n = 5) | 11.1 (6.3) (n = 11) |
Data are presented as mean (SD).