Health care use, quality of life, clinical events, socioeconomic status, and mortality according to ITI treatment among people with severe hemophilia A with inhibitors
| Number included . | ITI vs no ITI . | Successful ITI vs partially successful or failed ITI . | ||||
|---|---|---|---|---|---|---|
| 555 . | 485 . | |||||
| aOR . | 95% CI . | aOR . | 95% CI . | |||
| Clinical events | ||||||
| Number of treated bleeds∗ | 0.71 | 0.67 | 0.74 | 0.82 | 0.76 | 0.89 |
| Joint procedure | 1.29 | 0.61 | 2.76 | 0.60 | 0.38 | 0.95 |
| Health care use | ||||||
| Hospitalization | 0.30 | 0.15 | 0.58 | 0.36 | 0.23 | 0.58 |
| ED visit | 0.58 | 0.30 | 1.11 | 0.42 | 0.28 | 0.64 |
| Quality of life | ||||||
| Chronic pain | 0.35 | 0.17 | 0.73 | 0.40 | 0.26 | 0.60 |
| Limited function | 0.32 | 0.16 | 0.65 | 0.38 | 0.24 | 0.63 |
| Missed days∗,† | 0.89 | 0.60 | 1.31 | 0.56 | 0.50 | 0.62 |
| Socioeconomic status | ||||||
| Unemployed‡ | 0.42 | 0.15 | 1.22 | 0.81 | 0.42 | 1.57 |
| Disabled | 1.11 | 0.41 | 3.04 | 0.81 | 0.40 | 1.66 |
| Low education§ | 0.36 | 0.14 | 0.93 | 0.86 | 0.43 | 1.74 |
| aRR | 95% CI | aRR | 95% CI | |||
| Death‖ | 0.97 | 0.33 | 2.81 | -- | -- | |
| Death among people aged ≥20 y¶ | 0.68 | 0.20 | 2.31 | -- | -- | |
| Number included . | ITI vs no ITI . | Successful ITI vs partially successful or failed ITI . | ||||
|---|---|---|---|---|---|---|
| 555 . | 485 . | |||||
| aOR . | 95% CI . | aOR . | 95% CI . | |||
| Clinical events | ||||||
| Number of treated bleeds∗ | 0.71 | 0.67 | 0.74 | 0.82 | 0.76 | 0.89 |
| Joint procedure | 1.29 | 0.61 | 2.76 | 0.60 | 0.38 | 0.95 |
| Health care use | ||||||
| Hospitalization | 0.30 | 0.15 | 0.58 | 0.36 | 0.23 | 0.58 |
| ED visit | 0.58 | 0.30 | 1.11 | 0.42 | 0.28 | 0.64 |
| Quality of life | ||||||
| Chronic pain | 0.35 | 0.17 | 0.73 | 0.40 | 0.26 | 0.60 |
| Limited function | 0.32 | 0.16 | 0.65 | 0.38 | 0.24 | 0.63 |
| Missed days∗,† | 0.89 | 0.60 | 1.31 | 0.56 | 0.50 | 0.62 |
| Socioeconomic status | ||||||
| Unemployed‡ | 0.42 | 0.15 | 1.22 | 0.81 | 0.42 | 1.57 |
| Disabled | 1.11 | 0.41 | 3.04 | 0.81 | 0.40 | 1.66 |
| Low education§ | 0.36 | 0.14 | 0.93 | 0.86 | 0.43 | 1.74 |
| aRR | 95% CI | aRR | 95% CI | |||
| Death‖ | 0.97 | 0.33 | 2.81 | -- | -- | |
| Death among people aged ≥20 y¶ | 0.68 | 0.20 | 2.31 | -- | -- | |
Data were collected from the CC registry between 2013 to 2017; models are adjusted for: age, HIV and HCV infection, and race/ethnicity. Bold values are statistically significant.
Abbreviations are explained in Table 2.
Log binomial models to account for overdispersion.
Among students and employed adults.
Among adults aged 22 to 64 years.
Defined as those with a high school degree or less, among adults aged ≥22 years.
Poisson models are adjusted for: age, HIV, HCV infection, and race/ethnicity.
Poisson models are that restricted on age and are adjusted for HIV, HCV infection, and race/ethnicity.