Univariable and multivariable analysis of risk factors, hematologic diseases, and related gene mutations for ABO antigen weakness
| Factors . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| Odds ratio (95% CI) . | P value . | Odds ratio (95% CI) . | P value . | |
| AML | 4.16 (2.50-6.92) | < .001 | 2.55 (1.12-5.83) | .026 |
| MDS | 3.60 (2.00-6.46) | < .001 | 6.94 (2.86-16.83) | < .001 |
| ALL | 0.60 (0.24-1.53) | .286 | ||
| AA | 0.80 (0.11-5.95) | .824 | ||
| RUNX1 | 6.27 (3.15-12.50) | < .001 | 4.25 (1.77-10.21) | .001 |
| GATA2 | 3.64 (0.43-30.67) | .235 | ||
| CEBPA | 36.98 (18.38-74.39) | < .001 | 43.70 (18.12-105.40) | < .001 |
| NRAS | 2.91 (1.47-5.76) | .002 | 3.37 (1.46-7.79) | .005 |
| TET2 | 2.22 (1.06-4.62) | .034 | 0.85 (0.35-2.11) | .730 |
| U2AF1 | 11.46 (4.75-27.68) | < .001 | 8.12 (2.86-23.03) | < .001 |
| ASXL1 | 2.80 (1.22-6.41) | .015 | 0.69 (0.25-1.91) | .477 |
| FLT3 | 1.42 (0.60-3.37) | .431 | ||
| PTPN11 | 4.66 (1.87-11.63) | .001 | 4.52 (1.51-13.50) | .007 |
| Factors . | Univariable . | Multivariable . | ||
|---|---|---|---|---|
| Odds ratio (95% CI) . | P value . | Odds ratio (95% CI) . | P value . | |
| AML | 4.16 (2.50-6.92) | < .001 | 2.55 (1.12-5.83) | .026 |
| MDS | 3.60 (2.00-6.46) | < .001 | 6.94 (2.86-16.83) | < .001 |
| ALL | 0.60 (0.24-1.53) | .286 | ||
| AA | 0.80 (0.11-5.95) | .824 | ||
| RUNX1 | 6.27 (3.15-12.50) | < .001 | 4.25 (1.77-10.21) | .001 |
| GATA2 | 3.64 (0.43-30.67) | .235 | ||
| CEBPA | 36.98 (18.38-74.39) | < .001 | 43.70 (18.12-105.40) | < .001 |
| NRAS | 2.91 (1.47-5.76) | .002 | 3.37 (1.46-7.79) | .005 |
| TET2 | 2.22 (1.06-4.62) | .034 | 0.85 (0.35-2.11) | .730 |
| U2AF1 | 11.46 (4.75-27.68) | < .001 | 8.12 (2.86-23.03) | < .001 |
| ASXL1 | 2.80 (1.22-6.41) | .015 | 0.69 (0.25-1.91) | .477 |
| FLT3 | 1.42 (0.60-3.37) | .431 | ||
| PTPN11 | 4.66 (1.87-11.63) | .001 | 4.52 (1.51-13.50) | .007 |
AA, aplastic anemia; ALL, acute lymphocytic leukemia; CI, confidence interval.