Most common nonhematologic AEs occurring in 10% or more of patients treated with add-on parsaclisib plus ruxolitinib
| Event, n (%) . | Daily-to-weekly dosing (n = 32) . | All-daily dosing (n = 42) . | Total (N = 74) . | |||
|---|---|---|---|---|---|---|
| All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | |
| Nausea | 10 (31) | 1 (3) | 7 (17) | 0 | 17 (23) | 1 (1) |
| Diarrhea | 9 (28) | 1 (3) | 7 (17) | 0 | 16 (22) | 1 (1) |
| Abdominal pain | 7 (22) | 1 (3) | 7 (17) | 0 | 14 (19) | 1 (1) |
| Fatigue | 9 (28) | 1 (3) | 5 (12) | 1 (2) | 14 (19) | 2 (3) |
| Cough | 7 (22) | 0 | 6 (14) | 0 | 13 (18) | 0 |
| Dyspnea | 5 (16) | 0 | 8 (19) | 2 (5) | 13 (18) | 2 (3) |
| Dizziness | 4 (13) | 0 | 8 (19) | 0 | 12 (16) | 0 |
| Fall | 6 (19) | 2 (6) | 6 (14) | 0 | 12 (16) | 2 (3) |
| Constipation | 6 (19) | 0 | 7 (17) | 0 | 11 (15) | 0 |
| Hyperuricemia | 4 (13) | 0 | 6 (14) | 0 | 10 (14) | 0 |
| Pruritus | 5 (16) | 1 (3) | 5 (12) | 0 | 10 (14) | 1 (1) |
| Arthralgia | 3 (9) | 0 | 6 (14) | 1 (2) | 9 (12) | 1 (1) |
| Back pain | 5 (16) | 1 (3) | 4 (10) | 0 | 9 (12) | 1 (1) |
| Epistaxis | 6 (19) | 0 | 3 (7) | 0 | 9 (12) | 0 |
| Blood creatinine increased | 4 (13) | 1 (3) | 4 (10) | 0 | 8 (11) | 1 (1) |
| Contusion | 8 (25) | 0 | 0 | 0 | 8 (11) | 0 |
| Insomnia | 1 (3) | 0 | 7 (17) | 0 | 8 (11) | 0 |
| Pain in extremity | 4 (13) | 0 | 4 (10) | 0 | 8 (11) | 0 |
| Pneumonia | 3 (9) | 3 (9) | 5 (12) | 2 (5) | 8 (11) | 5 (7) |
| Pyrexia | 5 (16) | 1 (3) | 3 (7) | 0 | 8 (11) | 1 (1) |
| Rash | 5 (16) | 0 | 3 (7) | 0 | 8 (11) | 0 |
| Upper respiratory tract infection | 3 (9) | 0 | 5 (12) | 0 | 8 (11) | 0 |
| Alanine aminotransferase increased | 2 (6) | 2 (6) | 5 (12) | 0 | 7 (10) | 2 (3) |
| Headache | 6 (19) | 0 | 1 (2) | 0 | 7 (10) | 0 |
| Nasal congestion | 4 (13) | 0 | 3 (7) | 0 | 7 (10) | 0 |
| Event, n (%) . | Daily-to-weekly dosing (n = 32) . | All-daily dosing (n = 42) . | Total (N = 74) . | |||
|---|---|---|---|---|---|---|
| All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | |
| Nausea | 10 (31) | 1 (3) | 7 (17) | 0 | 17 (23) | 1 (1) |
| Diarrhea | 9 (28) | 1 (3) | 7 (17) | 0 | 16 (22) | 1 (1) |
| Abdominal pain | 7 (22) | 1 (3) | 7 (17) | 0 | 14 (19) | 1 (1) |
| Fatigue | 9 (28) | 1 (3) | 5 (12) | 1 (2) | 14 (19) | 2 (3) |
| Cough | 7 (22) | 0 | 6 (14) | 0 | 13 (18) | 0 |
| Dyspnea | 5 (16) | 0 | 8 (19) | 2 (5) | 13 (18) | 2 (3) |
| Dizziness | 4 (13) | 0 | 8 (19) | 0 | 12 (16) | 0 |
| Fall | 6 (19) | 2 (6) | 6 (14) | 0 | 12 (16) | 2 (3) |
| Constipation | 6 (19) | 0 | 7 (17) | 0 | 11 (15) | 0 |
| Hyperuricemia | 4 (13) | 0 | 6 (14) | 0 | 10 (14) | 0 |
| Pruritus | 5 (16) | 1 (3) | 5 (12) | 0 | 10 (14) | 1 (1) |
| Arthralgia | 3 (9) | 0 | 6 (14) | 1 (2) | 9 (12) | 1 (1) |
| Back pain | 5 (16) | 1 (3) | 4 (10) | 0 | 9 (12) | 1 (1) |
| Epistaxis | 6 (19) | 0 | 3 (7) | 0 | 9 (12) | 0 |
| Blood creatinine increased | 4 (13) | 1 (3) | 4 (10) | 0 | 8 (11) | 1 (1) |
| Contusion | 8 (25) | 0 | 0 | 0 | 8 (11) | 0 |
| Insomnia | 1 (3) | 0 | 7 (17) | 0 | 8 (11) | 0 |
| Pain in extremity | 4 (13) | 0 | 4 (10) | 0 | 8 (11) | 0 |
| Pneumonia | 3 (9) | 3 (9) | 5 (12) | 2 (5) | 8 (11) | 5 (7) |
| Pyrexia | 5 (16) | 1 (3) | 3 (7) | 0 | 8 (11) | 1 (1) |
| Rash | 5 (16) | 0 | 3 (7) | 0 | 8 (11) | 0 |
| Upper respiratory tract infection | 3 (9) | 0 | 5 (12) | 0 | 8 (11) | 0 |
| Alanine aminotransferase increased | 2 (6) | 2 (6) | 5 (12) | 0 | 7 (10) | 2 (3) |
| Headache | 6 (19) | 0 | 1 (2) | 0 | 7 (10) | 0 |
| Nasal congestion | 4 (13) | 0 | 3 (7) | 0 | 7 (10) | 0 |