Participant characteristics
| Clinical parameters . | N = 20 (%) . |
|---|---|
| Sex | |
| Male | 7 (35%) |
| Female | 13 (65%) |
| Age median (range) | 43.5 (19-62) |
| Genotype before HSCT | |
| AA | 3 (15%) |
| AS | 6 (30%) |
| SS | 3 (15%) |
| Sβ+ | 1 (5%) |
| SC | 2 (10%) |
| Genotype SCD after HSCT (N = 5), SS | 5 (100%) |
| Alpha globin gene mutation | |
| Single mutation | 10 (50%) |
| No mutation detected | 10 (50%) |
| Hematologic data at time of enrollment (mean, SD) | |
| WBC (K/mcL) | 6.6 ± 3.1 |
| RBC (M/mcL) | 4.0 ± 0.9 |
| Hemoglobin (g/dL) | 11.5 ± 2.3 |
| Hematocrit (%) | 34.2 ± 7.5 |
| MCV (fL) | 85.9 ± 7.6 |
| Platelet count (K/mcL) | 308.2 ± 116.4 |
| ARC (K/mcL) | 125.8 ± 82.2 |
| HbF (%) | 3.2 ± 6.4 |
| HbA (%) | 48.2 ± 32.9 |
| HbA2 (%) | 3.2 ± 0.5 |
| HbS (%) | 41.2 ± 24.1 |
| HbC (%) | 43.2 ± 0 |
| AST (U/L) | 22.6 ± 8.8 |
| Total bilirubin (mg/dL) | 1.0 ± 0.9 |
| LDH (U/L) | 254.2 ± 111.2 |
| Study duration mean number of days (range) | 103 (35-147) |
| Clinical parameters . | N = 20 (%) . |
|---|---|
| Sex | |
| Male | 7 (35%) |
| Female | 13 (65%) |
| Age median (range) | 43.5 (19-62) |
| Genotype before HSCT | |
| AA | 3 (15%) |
| AS | 6 (30%) |
| SS | 3 (15%) |
| Sβ+ | 1 (5%) |
| SC | 2 (10%) |
| Genotype SCD after HSCT (N = 5), SS | 5 (100%) |
| Alpha globin gene mutation | |
| Single mutation | 10 (50%) |
| No mutation detected | 10 (50%) |
| Hematologic data at time of enrollment (mean, SD) | |
| WBC (K/mcL) | 6.6 ± 3.1 |
| RBC (M/mcL) | 4.0 ± 0.9 |
| Hemoglobin (g/dL) | 11.5 ± 2.3 |
| Hematocrit (%) | 34.2 ± 7.5 |
| MCV (fL) | 85.9 ± 7.6 |
| Platelet count (K/mcL) | 308.2 ± 116.4 |
| ARC (K/mcL) | 125.8 ± 82.2 |
| HbF (%) | 3.2 ± 6.4 |
| HbA (%) | 48.2 ± 32.9 |
| HbA2 (%) | 3.2 ± 0.5 |
| HbS (%) | 41.2 ± 24.1 |
| HbC (%) | 43.2 ± 0 |
| AST (U/L) | 22.6 ± 8.8 |
| Total bilirubin (mg/dL) | 1.0 ± 0.9 |
| LDH (U/L) | 254.2 ± 111.2 |
| Study duration mean number of days (range) | 103 (35-147) |
AST, aspartate transaminase; HbA, adult hemoglobin; HbA2, hemoglobin A2; HbC, hemoglobin C; HbS, sickle hemoglobin; MCV, mean corpuscular volume; WBC, white blood cell count.