Table 1. Genome-wide significant... | American Society of Hematology

Table 1.

Genome-wide significant independent loci of GWAS meta-analysis for severe GT

CHR	BP	SNP	A1	A2	EAF	Gene	Consequence	Effect	Meta-analysis		Longgang		Baoan
CHR	BP	SNP	A1	A2	EAF	Gene	Consequence	Effect	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
1	156 899 255	rs12566888	G	T	0.5868	PEAR1	intron_variant	MODIFIER	2.00 (1.69-2.38)	1.07 × 10^–15	2.17 (1.75-2.70)	2.79 × 10^–12	1.78 (1.35-2.32)	4.35 × 10^–5
20	59 022 916	rs415064	C	G	0.0888	TUBB1	missense_variant	MODERATE	1.91 (1.59-2.28)	2.08 × 10^–12	2.01 (1.61-2.51)	7.37 × 10^–10	1.72 (1.27-2.34)	4.97 × 10^–4

CHR	BP	SNP	A1	A2	EAF	Gene	Consequence	Effect	Meta-analysis		Longgang		Baoan
CHR	BP	SNP	A1	A2	EAF	Gene	Consequence	Effect	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
1	156 899 255	rs12566888	G	T	0.5868	PEAR1	intron_variant	MODIFIER	2.00 (1.69-2.38)	1.07 × 10^–15	2.17 (1.75-2.70)	2.79 × 10^–12	1.78 (1.35-2.32)	4.35 × 10^–5
20	59 022 916	rs415064	C	G	0.0888	TUBB1	missense_variant	MODERATE	1.91 (1.59-2.28)	2.08 × 10^–12	2.01 (1.61-2.51)	7.37 × 10^–10	1.72 (1.27-2.34)	4.97 × 10^–4

A1, effect allele; A2, noneffect allele; BP, base pair position; CHR, chromosome; EAF, effect allele frequency.