Exhaustion of RTX-mediated cytotoxic mechanisms
| Mechanism . | Observation . | Possible remedy . |
|---|---|---|
| ADCC | Reduced CD16 and CD25 on NK cells | Provide CD4+ T cells in TME1 |
| ADCP | Reduced FcγR on macrophages | Lower dose at more frequent intervals (48 h)5,7 |
| CDC | Reduced CH50 | Infuse fresh frozen plasma3 |
| Mechanism . | Observation . | Possible remedy . |
|---|---|---|
| ADCC | Reduced CD16 and CD25 on NK cells | Provide CD4+ T cells in TME1 |
| ADCP | Reduced FcγR on macrophages | Lower dose at more frequent intervals (48 h)5,7 |
| CDC | Reduced CH50 | Infuse fresh frozen plasma3 |
ADCP, antibody-dependent cellular phagocytosis mediated by macrophages; CDC, complement-mediated cytotoxicity; CH50, complement titer; FcγR, Fc gamma receptor.