Table 1. Commonly altered pathways in... | American Society of Hematology

Table 1.

Commonly altered pathways in ML-DS

Gene/cluster	Frequency (Klusmann)²¹	Frequency (Ogawa)²²
GATA1	100%	100%
Chromatin configuration∗	47%	65%
STAG2, RAD21, SMC1A, SMC3, NIPBL, CTCF
Signaling	50%	35%†
JAK1, JAK2, JAK3, MPL, KIT, SH2B3
Epigenetic	36%	41%
EZH2, SUZ12, KANSL1
RAS family	14%‡	16%
NRAS, KRAS, NF1, PTPN11
CSF2Rβ	4.7%	ND§

Gene/cluster	Frequency (Klusmann)²¹	Frequency (Ogawa)²²
GATA1	100%	100%
Chromatin configuration∗	47%	65%
STAG2, RAD21, SMC1A, SMC3, NIPBL, CTCF
Signaling	50%	35%†
JAK1, JAK2, JAK3, MPL, KIT, SH2B3
Epigenetic	36%	41%
EZH2, SUZ12, KANSL1
RAS family	14%‡	16%
NRAS, KRAS, NF1, PTPN11
CSF2Rβ	4.7%	ND§

Percentage of cases with at least 1 mutation of genes in the cluster.

KIT mutations were not reported.

PTPN11 mutations were not reported.

CSF2Rβ mutations were not reported.