Peptide clusters that were used as predictors in both the logistic regression model and the random forest classifier model
| Core motif . | Mean peptide count in INH– group . | Mean peptide count in INH+ group . | Fold change . | FVIII domain . | Number of unique peptides in cluster (%) . | Peptide count of cluster (%) . |
|---|---|---|---|---|---|---|
| kxPxstw | 133 | 1826 | 13.70 | - | 24 (0.09%) | 55 764 (0.16%) |
| hntMels | 38 | 119 | 3.10 | - | 11 (0.04%) | 20 460 (0.06%) |
| hTnln | 151 | 454 | 3.01 | A3 | 48 (0.17%) | 66 660 (0.19%) |
| nqkms | 140 | 365 | 2.60 | A2 | 31 (0.11%) | 66 660 (0.19%) |
| dxxYxlxm | 438 | 1114 | 2.54 | - | 34 (0.12%) | 63 368 (0.18%) |
| Yvntxxxt | 193 | 475 | 2.46 | - | 11 (0.04%) | 25 499 (0.07%) |
| LtqM | 159 | 302 | 1.90 | - | 31 (0.11%) | 61 253 (0.17%) |
| pQyxnxxk | 454 | 738 | 1.63 | - | 51 (0.18%) | 52 743 (0.15%) |
| sxnKP | 325 | 483 | 1.49 | - | 53 (0.19%) | 52 537 (0.15%) |
| WDVpPxxxxt | 301 | 445 | 1.48 | - | 21 (0.08%) | 33 105 (0.09%) |
| KxxHyxk | 459 | 459 | 1.00 | - | 15 (0.05%) | 39 173 (0.11%) |
| qTAkfh | 41 | 40 | 0.96 | - | 41 (0.15%) | 48 928 (0.14%) |
| Core motif . | Mean peptide count in INH– group . | Mean peptide count in INH+ group . | Fold change . | FVIII domain . | Number of unique peptides in cluster (%) . | Peptide count of cluster (%) . |
|---|---|---|---|---|---|---|
| kxPxstw | 133 | 1826 | 13.70 | - | 24 (0.09%) | 55 764 (0.16%) |
| hntMels | 38 | 119 | 3.10 | - | 11 (0.04%) | 20 460 (0.06%) |
| hTnln | 151 | 454 | 3.01 | A3 | 48 (0.17%) | 66 660 (0.19%) |
| nqkms | 140 | 365 | 2.60 | A2 | 31 (0.11%) | 66 660 (0.19%) |
| dxxYxlxm | 438 | 1114 | 2.54 | - | 34 (0.12%) | 63 368 (0.18%) |
| Yvntxxxt | 193 | 475 | 2.46 | - | 11 (0.04%) | 25 499 (0.07%) |
| LtqM | 159 | 302 | 1.90 | - | 31 (0.11%) | 61 253 (0.17%) |
| pQyxnxxk | 454 | 738 | 1.63 | - | 51 (0.18%) | 52 743 (0.15%) |
| sxnKP | 325 | 483 | 1.49 | - | 53 (0.19%) | 52 537 (0.15%) |
| WDVpPxxxxt | 301 | 445 | 1.48 | - | 21 (0.08%) | 33 105 (0.09%) |
| KxxHyxk | 459 | 459 | 1.00 | - | 15 (0.05%) | 39 173 (0.11%) |
| qTAkfh | 41 | 40 | 0.96 | - | 41 (0.15%) | 48 928 (0.14%) |
Total number of unique peptides were 27 775. Total peptide count was 35 452 858. The “-” indicates lack of good alignment on linear sequence of FVIII.