Mean count of peptide clusters, stratified by inhibitor status, F8 gene mutation, and FVIII product type
| . | Inhibitor status . | F8 Gene mutation∗ . | FVIII product type . | |||||
|---|---|---|---|---|---|---|---|---|
| Inhibitor-negative (n = 83) . | Inhibitor-positive, total (n = 39) . | Inhibitor-positive, low-titer (n = 15) . | Inhibitor-positive, high-titer (n = 24) . | Non-null mutation (n = 16) . | Null mutation (n = 102) . | rFVIII product (n = 61) . | pdFVIII product (n = 61) . | |
| Mean peptide count (SD) | ||||||||
| kxPxstw | 133 (119) | 1830 (9810) | 4360 (15800) | 240 (337) | 145 (119) | 779 (6070) | 1190 (7850) | 164 (196) |
| hntMels | 38.5 (44.8) | 119 (266) | 256 (398) | 33.4 (28.7) | 88.5 (264) | 61.6 (139) | 91.8 (212) | 36.6 (61.5) |
| hTnln | 151 (372) | 454 (1540) | 850 (2370) | 206 (564) | 295 (590) | 247 (985) | 350 (1260) | 145 (345) |
| nqkms | 140 (199) | 365 (1240) | 168 (139) | 489 (1570) | 159 (215) | 223 (784) | 267 (996) | 157 (223) |
| dxxYxlxm | 438 (1590) | 1110 (3850) | 451 (840) | 1530 (4850) | 332 (440) | 717 (2770) | 889 (3140) | 420 (1750) |
| Yvntxxxt | 193 (290) | 475 (891) | 448 (523) | 492 (1070) | 185 (167) | 299 (615) | 286 (532) | 280 (608) |
| LtqM | 159 (483) | 302 (1000) | 159 (316) | 391 (1250) | 61.3 (106) | 234 (752) | 187 (797) | 222 (573) |
| pQyxnxxk | 454 (1170) | 738 (1890) | 109 (157) | 1130 (2340) | 176 (189) | 614 (1560) | 683 (1540) | 407 (1320) |
| sxnKP | 325 (674) | 483 (858) | 717 (995) | 337 (746) | 208 (293) | 413 (794) | 459 (888) | 293 (543) |
| WDVpPxxxxt | 301 (464) | 445 (1130) | 277 (277) | 549 (1430) | 331 (468) | 358 (791) | 330 (520) | 364 (917) |
| KxxHyxk | 459 (3120) | 459 (1880) | 99.5 (155) | 684 (2380) | 65.6 (164) | 532 (3030) | 617 (3630) | 301 (1510) |
| qTAkfh | 41.5 (103) | 39.7 (82.9) | 39.3 (97.9) | 40.0 (74.3) | 88.9 (164) | 34.3 (81.9) | 44.8 (104) | 37.0 (88.6) |
| . | Inhibitor status . | F8 Gene mutation∗ . | FVIII product type . | |||||
|---|---|---|---|---|---|---|---|---|
| Inhibitor-negative (n = 83) . | Inhibitor-positive, total (n = 39) . | Inhibitor-positive, low-titer (n = 15) . | Inhibitor-positive, high-titer (n = 24) . | Non-null mutation (n = 16) . | Null mutation (n = 102) . | rFVIII product (n = 61) . | pdFVIII product (n = 61) . | |
| Mean peptide count (SD) | ||||||||
| kxPxstw | 133 (119) | 1830 (9810) | 4360 (15800) | 240 (337) | 145 (119) | 779 (6070) | 1190 (7850) | 164 (196) |
| hntMels | 38.5 (44.8) | 119 (266) | 256 (398) | 33.4 (28.7) | 88.5 (264) | 61.6 (139) | 91.8 (212) | 36.6 (61.5) |
| hTnln | 151 (372) | 454 (1540) | 850 (2370) | 206 (564) | 295 (590) | 247 (985) | 350 (1260) | 145 (345) |
| nqkms | 140 (199) | 365 (1240) | 168 (139) | 489 (1570) | 159 (215) | 223 (784) | 267 (996) | 157 (223) |
| dxxYxlxm | 438 (1590) | 1110 (3850) | 451 (840) | 1530 (4850) | 332 (440) | 717 (2770) | 889 (3140) | 420 (1750) |
| Yvntxxxt | 193 (290) | 475 (891) | 448 (523) | 492 (1070) | 185 (167) | 299 (615) | 286 (532) | 280 (608) |
| LtqM | 159 (483) | 302 (1000) | 159 (316) | 391 (1250) | 61.3 (106) | 234 (752) | 187 (797) | 222 (573) |
| pQyxnxxk | 454 (1170) | 738 (1890) | 109 (157) | 1130 (2340) | 176 (189) | 614 (1560) | 683 (1540) | 407 (1320) |
| sxnKP | 325 (674) | 483 (858) | 717 (995) | 337 (746) | 208 (293) | 413 (794) | 459 (888) | 293 (543) |
| WDVpPxxxxt | 301 (464) | 445 (1130) | 277 (277) | 549 (1430) | 331 (468) | 358 (791) | 330 (520) | 364 (917) |
| KxxHyxk | 459 (3120) | 459 (1880) | 99.5 (155) | 684 (2380) | 65.6 (164) | 532 (3030) | 617 (3630) | 301 (1510) |
| qTAkfh | 41.5 (103) | 39.7 (82.9) | 39.3 (97.9) | 40.0 (74.3) | 88.9 (164) | 34.3 (81.9) | 44.8 (104) | 37.0 (88.6) |
SD, standard deviation.
Four patients were excluded from this analysis as their F8 gene mutation was unknown.