The cause of death in 7.1% of participants in the trial
| Age at BMT, y . | Sex, recipient/donor . | Days posttransplant . | Cause of death . |
|---|---|---|---|
| 40.2 | Female/female | 1265 | Primary cause of death: cardio-respiratory failure Secondary cause of death: presumed COVID-19 infection |
| 1.3 | Female/female | 323 | Primary cause of death: disseminated adenovirus infection Secondary cause of death: MAS, GI GVHD, and multiorgan failure |
| 5.3 | Female/female | 509 | Primary cause of death: Pneumococcal sepsis Secondary cause of death: ARDS, ischemia, and necrosis in all extremities requiring extensive plastic surgery, and multiorgan failure |
| 18.7 | Female/female | 132 | Primary cause of death: disseminated adenovirus infection Secondary cause of death: multiorgan failure |
| 36.0 | Female/female | 248 | Primary cause of death: respiratory failure and worsening pulmonary HTN Secondary cause of death: poor graft function (platelet and RBC); CMV reactivation, TA-TMA, PRES, and acute acute-on on-chronic renal failure; recurrent GI bleeding; recurrent C. diff and salmonella infections; BK virus cystitis; right internal jugular vein thrombosis |
| Age at BMT, y . | Sex, recipient/donor . | Days posttransplant . | Cause of death . |
|---|---|---|---|
| 40.2 | Female/female | 1265 | Primary cause of death: cardio-respiratory failure Secondary cause of death: presumed COVID-19 infection |
| 1.3 | Female/female | 323 | Primary cause of death: disseminated adenovirus infection Secondary cause of death: MAS, GI GVHD, and multiorgan failure |
| 5.3 | Female/female | 509 | Primary cause of death: Pneumococcal sepsis Secondary cause of death: ARDS, ischemia, and necrosis in all extremities requiring extensive plastic surgery, and multiorgan failure |
| 18.7 | Female/female | 132 | Primary cause of death: disseminated adenovirus infection Secondary cause of death: multiorgan failure |
| 36.0 | Female/female | 248 | Primary cause of death: respiratory failure and worsening pulmonary HTN Secondary cause of death: poor graft function (platelet and RBC); CMV reactivation, TA-TMA, PRES, and acute acute-on on-chronic renal failure; recurrent GI bleeding; recurrent C. diff and salmonella infections; BK virus cystitis; right internal jugular vein thrombosis |
A total of 5 of 70 participants died due to infections.
ARDS, acute respiratory distress syndrome; C. diff, Clostridioides difficile; CMV, cytomegalovirus; GI, gastrointestinal; MAS, macrophage activation syndrome; PRES, posterior reversible encephalopathy syndrome; RBC, red blood cell; TA-TMA, transplant-associated thrombotic microangiopathy.