Median ADAMTS13 activity, ADAMTS13 antigen, and anti-ADAMTS13 IgG antibody levels in patient samples with open and closed conformations in remission (ADAMTS13 activity more than 60%)
| . | Open conformation . | Closed conformation . | P value . |
|---|---|---|---|
| Number (n = 119) | 51 (43%) | 68 (57%) | |
| ADAMTS13 activity (IQR) | 77.9% (69%-91%) | 102% (83%-114.4%) | <.0001 |
| ADAMTS13 antigen | 102% (82.2%-120.1%) | 124.1% (103.5%-142.9%) | .0002 |
| Anti-ADAMTS13 IgG antibody | 4% (2%-8.5%) | 2.6% (1%-3.5%) | .0005 |
| . | Open conformation . | Closed conformation . | P value . |
|---|---|---|---|
| Number (n = 119) | 51 (43%) | 68 (57%) | |
| ADAMTS13 activity (IQR) | 77.9% (69%-91%) | 102% (83%-114.4%) | <.0001 |
| ADAMTS13 antigen | 102% (82.2%-120.1%) | 124.1% (103.5%-142.9%) | .0002 |
| Anti-ADAMTS13 IgG antibody | 4% (2%-8.5%) | 2.6% (1%-3.5%) | .0005 |
Cases with an open ADAMTS13 conformation in remission had a normal but significantly lower ADAMTS13 activity and ADAMTS13 antigen levels compared with cases with a closed conformation.
IQR, interquartile range.