Median ADAMTS13 activity, ADAMTS13 antigen, and anti-ADAMTS13 IgG antibody levels in patient samples with open and closed conformations using peak ADAMTS13 activity
| . | Open conformation . | Closed conformation . | P value . |
|---|---|---|---|
| Number (n = 60) | 14/60 (23%) | 46/60 (77%) | |
| ADAMTS13 activity (IQR) | 89.3% (76.3%-107.3%) | 108.1% (94%-117.3%) | .02 |
| ADAMTS13 antigen | 113.8% (95.8%-138.2%) | 124.1% (107.3%-143.6%) | .34 |
| Anti-ADAMTS13 IgG antibody | 3.5% (1.8%-5.3%) | 3% (1%-4.3%) | .26 |
| . | Open conformation . | Closed conformation . | P value . |
|---|---|---|---|
| Number (n = 60) | 14/60 (23%) | 46/60 (77%) | |
| ADAMTS13 activity (IQR) | 89.3% (76.3%-107.3%) | 108.1% (94%-117.3%) | .02 |
| ADAMTS13 antigen | 113.8% (95.8%-138.2%) | 124.1% (107.3%-143.6%) | .34 |
| Anti-ADAMTS13 IgG antibody | 3.5% (1.8%-5.3%) | 3% (1%-4.3%) | .26 |
Cases with an open ADAMTS13 conformation at peak ADAMTS13 activity had normal but significantly lower ADAMTS13 activity than cases with a closed conformation. No discernible difference in anti-ADAMTS13 IgG antibody and ADAMTS13 antigen was observed.