Rates of relapse (clinical and ADAMTS13) within 1 and 2 years according to ADAMTS13 conformation at peak ADAMTS13 activity after acute episode
| . | Within 1 y . | Within 2 y . | Overall . | |||
|---|---|---|---|---|---|---|
| Relapse . | No relapse . | Relapse . | No relapse . | Relapse . | No relapse . | |
| Open conformation (n = 13) | 6∗ (46%) | 7 (54%) | 8† (62%) | 5 (39%) | 8 (61.5%) | 5 (38.5%) |
| Closed conformation (n = 43) | 4‡ (9%) | 39 (91%) | 10§ (23%) | 33 (77%) | 19 (44%) | 24 (56%) |
| P value; OR; 95% CI | .007; 8.4; 2-30.2 | .02; 5.3; 1.4-19.1 | .35 | |||
| . | Within 1 y . | Within 2 y . | Overall . | |||
|---|---|---|---|---|---|---|
| Relapse . | No relapse . | Relapse . | No relapse . | Relapse . | No relapse . | |
| Open conformation (n = 13) | 6∗ (46%) | 7 (54%) | 8† (62%) | 5 (39%) | 8 (61.5%) | 5 (38.5%) |
| Closed conformation (n = 43) | 4‡ (9%) | 39 (91%) | 10§ (23%) | 33 (77%) | 19 (44%) | 24 (56%) |
| P value; OR; 95% CI | .007; 8.4; 2-30.2 | .02; 5.3; 1.4-19.1 | .35 | |||
Patients with a closed ADAMTS13 conformation at peak ADAMTS13 activity had significantly lower relapse rates within 1 year (P = .007; OR, 8.4 (2-30.2). Within 2 years, the risk of relapse remains significantly lower in patients with a closed ADAMTS13 conformation. However, there was a higher risk of relapse observed in patients with an open ADAMTS13 conformation, although patient numbers were small.
CI, confidence interval
Two clinical relapses and 4 ADAMTS13 relapses.
Two clinical relapses and 6 ADAMTS13 relapses.
One clinical relapse and 3 ADAMTS13 relapses.
One clinical relapse and 9 ADAMTS13 relapses.