Table 1. Multivariable Cox regression... | American Society of Hematology

Table 1.

Multivariable Cox regression for associations between EFS and somatic mutations identified by univariable Cox regression and LASSO

	Frequency	Events∗	Mutations not combined (unadjusted for other prognostic factors)				Mutations not combined (adjusted for other prognostic factors†)
	Frequency	Events∗	HR	95% CI		P value	HR	95% CI		P value
ZBTB7A	24	7	3.308	1.285	8.515	.013	3.119	1.150	8.459	.025
JAK2	12	5	3.100	1.069	8.989	.037	3.119	0.953	10.208	.060
CDKN2A	7	5	10.842	3.431	34.256	<.001	9.815	1.702	56.591	.011
TP53	4	3	21.634	5.088	91.981	<.001	12.229	2.516	59.435	.002
Age at diagnosis, y							1.401	0.793	2.476	.246
Complex							0.962	0.269	3.441	.953
Trisomy 8							0.182	0.024	1.392	.101
Monosomy 7							1.116	0.235	5.306	.890
	Frequency	Events∗	Mutations combined (unadjusted for other prognostic factors)				Mutations combined (adjusted for other prognostic factors† )
	Frequency	Events∗	HR	95% CI		Pvalue	HR	95% CI		Pvalue
Any of 4 mutations	39	14	7.295	3.055	17.420	<.001	5.762	2.341	14.186	<.001
Age at diagnosis, y							1.366	0.841	2.219	.207
Complex							1.648	0.624	4.356	.313
Trisomy 8							0.206	0.027	1.560	.126
Monosomy 7							0.753	0.167	3.401	.712

	Frequency	Events∗	Mutations not combined (unadjusted for other prognostic factors)				Mutations not combined (adjusted for other prognostic factors†)
	Frequency	Events∗	HR	95% CI		P value	HR	95% CI		P value
ZBTB7A	24	7	3.308	1.285	8.515	.013	3.119	1.150	8.459	.025
JAK2	12	5	3.100	1.069	8.989	.037	3.119	0.953	10.208	.060
CDKN2A	7	5	10.842	3.431	34.256	<.001	9.815	1.702	56.591	.011
TP53	4	3	21.634	5.088	91.981	<.001	12.229	2.516	59.435	.002
Age at diagnosis, y							1.401	0.793	2.476	.246
Complex							0.962	0.269	3.441	.953
Trisomy 8							0.182	0.024	1.392	.101
Monosomy 7							1.116	0.235	5.306	.890
	Frequency	Events∗	Mutations combined (unadjusted for other prognostic factors)				Mutations combined (adjusted for other prognostic factors† )
	Frequency	Events∗	HR	95% CI		Pvalue	HR	95% CI		Pvalue
Any of 4 mutations	39	14	7.295	3.055	17.420	<.001	5.762	2.341	14.186	<.001
Age at diagnosis, y							1.366	0.841	2.219	.207
Complex							1.648	0.624	4.356	.313
Trisomy 8							0.206	0.027	1.560	.126
Monosomy 7							0.753	0.167	3.401	.712

LASSO, least absolute shrinkage and selection operator.

Events included induction failure, relapse, or nonrelapse mortality.

DS karyotype was also examined, but none of events developed in patients with DS karyotype, and DS karyotype was not included in the adjustment.