Genes defining the bystander-specific gene signature “bystander signature 1”
| Upregulated genes . | Downregulated genes . | ||
|---|---|---|---|
| Gene name (human ortholog) . | Log fold change . | Gene name . | Log fold change . |
| KIR3DL2 | 10.26 | EZH2 | −1.73 |
| CD160 | 9.21 | SLC2A3 | −1.78 |
| IGFBP3 | 8.31 | GNG2 | −1.83 |
| ABCB4 | 7.72 | LYST | −1.97 |
| ENSMMUG00000050862 (KLRC2) | 7.62 | LTB | −1.98 |
| SPRY2 | 7.58 | TESPA1 | −1.98 |
| XCL1 | 7.44 | SATB1 | −2.11 |
| CCL5 | 7.36 | CCR7 | −2.16 |
| NUGGC | 6.65 | ICOS | −2.24 |
| ENSMMUG00000063583 (GNLY) | 6.63 | SIT1 | −2.25 |
| ENSMMUG00000013779 | 5.95 | DUSP16 | −2.38 |
| CCR9 | 5.93 | SH2D1A | −2.41 |
| KLRD1 | 5.52 | PTPRJ | −2.43 |
| ENSMMUG00000054501 9 (TRGV) | 5.47 | H1-3 | −2.52 |
| CD101 | 5.04 | SLFN12L | −2.71 |
| PPP2R2B | 4.89 | PDE4B | −2.71 |
| SERPINB6 | 4.61 | PGAP1 | −2.72 |
| PLCG2 | 4.55 | CFP | −2.75 |
| ENSMMUG00000057791 (TRDV) | 4.54 | ANTXR2 | −2.88 |
| LAT2 | 4.48 | GPR183 | −2.93 |
| ANK3 | 4.16 | SPOCK2 | −3.37 |
| THAP6 | 4.03 | MT1E | −3.46 |
| JAKMIP2 | 4.02 | S1PR1 | −3.89 |
| THY1 | 3.96 | LEF1 | −4.09 |
| MATK | 3.87 | TOB1 | −4.13 |
| ENTPD1 | 3.71 | CD4 | −4.47 |
| ENSMMUG00000032338 (SMIM10) | 3.62 | PLAC8 | −4.59 |
| TIGIT | 3.59 | CD28 | −5.29 |
| OTUD5 | 3.52 | SELL | −5.68 |
| FCRL6 | 3.44 | — | — |
| NCALD | 3.32 | — | — |
| NKG7 | 3.17 | — | — |
| ITGA1 | 3.03 | — | — |
| NR3C2 | 2.88 | — | — |
| DAPK2 | 2.79 | — | — |
| SPINK2 | 2.73 | — | — |
| PRR29 | 2.73 | — | — |
| STX3 | 2.34 | — | — |
| RIN3 | 2.32 | — | — |
| NR4A1 | 2.27 | — | — |
| S100A6 | 2.23 | — | — |
| UBASH3B | 2.13 | — | — |
| CPQ | 2.11 | — | — |
| Upregulated genes . | Downregulated genes . | ||
|---|---|---|---|
| Gene name (human ortholog) . | Log fold change . | Gene name . | Log fold change . |
| KIR3DL2 | 10.26 | EZH2 | −1.73 |
| CD160 | 9.21 | SLC2A3 | −1.78 |
| IGFBP3 | 8.31 | GNG2 | −1.83 |
| ABCB4 | 7.72 | LYST | −1.97 |
| ENSMMUG00000050862 (KLRC2) | 7.62 | LTB | −1.98 |
| SPRY2 | 7.58 | TESPA1 | −1.98 |
| XCL1 | 7.44 | SATB1 | −2.11 |
| CCL5 | 7.36 | CCR7 | −2.16 |
| NUGGC | 6.65 | ICOS | −2.24 |
| ENSMMUG00000063583 (GNLY) | 6.63 | SIT1 | −2.25 |
| ENSMMUG00000013779 | 5.95 | DUSP16 | −2.38 |
| CCR9 | 5.93 | SH2D1A | −2.41 |
| KLRD1 | 5.52 | PTPRJ | −2.43 |
| ENSMMUG00000054501 9 (TRGV) | 5.47 | H1-3 | −2.52 |
| CD101 | 5.04 | SLFN12L | −2.71 |
| PPP2R2B | 4.89 | PDE4B | −2.71 |
| SERPINB6 | 4.61 | PGAP1 | −2.72 |
| PLCG2 | 4.55 | CFP | −2.75 |
| ENSMMUG00000057791 (TRDV) | 4.54 | ANTXR2 | −2.88 |
| LAT2 | 4.48 | GPR183 | −2.93 |
| ANK3 | 4.16 | SPOCK2 | −3.37 |
| THAP6 | 4.03 | MT1E | −3.46 |
| JAKMIP2 | 4.02 | S1PR1 | −3.89 |
| THY1 | 3.96 | LEF1 | −4.09 |
| MATK | 3.87 | TOB1 | −4.13 |
| ENTPD1 | 3.71 | CD4 | −4.47 |
| ENSMMUG00000032338 (SMIM10) | 3.62 | PLAC8 | −4.59 |
| TIGIT | 3.59 | CD28 | −5.29 |
| OTUD5 | 3.52 | SELL | −5.68 |
| FCRL6 | 3.44 | — | — |
| NCALD | 3.32 | — | — |
| NKG7 | 3.17 | — | — |
| ITGA1 | 3.03 | — | — |
| NR3C2 | 2.88 | — | — |
| DAPK2 | 2.79 | — | — |
| SPINK2 | 2.73 | — | — |
| PRR29 | 2.73 | — | — |
| STX3 | 2.34 | — | — |
| RIN3 | 2.32 | — | — |
| NR4A1 | 2.27 | — | — |
| S100A6 | 2.23 | — | — |
| UBASH3B | 2.13 | — | — |
| CPQ | 2.11 | — | — |
Gene list for bystander signature 1. Listed genes are DE (up- and downregulated) in cluster 14 compared with all other cells in the data set for animal R.315.