Summary of primary systematic review findings
| Subject . | Update or new recommendation . | Previous recommendation . | Number of studies . | Comments . |
|---|---|---|---|---|
| Adults with newly diagnosed ITP | ||||
| Prednisone or dexamethasone | Update | 2019 recommendation 4 | 3 | |
| H. pylori eradication | Update | 2011 recommendations 7.3.A and 7.3.B | 2 | |
| IVIg | Update | 2011 recommendation 4.3A | 2 | |
| Combination therapy | New | 3 | Agents used in combination with steroids: all-trans retinoic acid mycophenolate mofetil rhTPO | |
| Children with newly diagnosed ITP | ||||
| Observation or IVIg | Update | 2019 recommendation 12 | 3 | |
| Prednisone or dexamethasone | Update | 2019 recommendation 15 | 1 | |
| Anti-D immunoglobulin or IVIg | Update | 2019 recommendation 17 | 2 | |
| IVIg with or without IV methylprednisolone | New | 1 | ||
| Adults with ITP for ≥3 mo who are corticosteroid dependent or failed corticosteroids | ||||
| TPO-RAs (avatrombopag, eltrombopag, hetrombopag and romiplostim) | Update | 2019 recommendations 7 and 9 | 17 | |
| Low-dose Rituximab | Update | 2019 recommendations 8 and 9 | 1 | |
| Splenectomy | Update | 2019 recommendations 7 and 8 | 1 | |
| Fostamatinib | New | 3 | ||
| Rituximab with or without cyclophosphamide | New | 1 | ||
| Rituximab with or without all-trans retinoic acid | New | 1 | ||
| Danazol with or without all-trans retinoic acid | New | 1 | ||
| Hydroxychloroquine | New | 1 | ||
| IVIg or eltrombopag for surgery | New | 1 | ||
| Children with ITP who have non-threatening mucosal bleeding and/or diminished quality of life and do not respond to first-line treatment | ||||
| TPO-RAs (eltrombopag and romiplostim) | Update | 2019 recommendations 19 and 20 | 3 | 1 included in both adult and peds |
| TPO-RAs and Rituximab | Update | Recommendation 19 | 1 | |
| Splenectomy | Update | 2019 recommendations 20 and 21 | 1 | Included in both adult and peds |
| Sirolimus vs cyclosporine | New | 1 | ||
| Hydroxychloroquine | New | 1 | ||
| Multiple comparison studies | ||||
| Comparative effectiveness in children with ITP | 1 | |||
| Network meta-analysis in adults with ITP | 2 | |||
| Multiple agents single-center experience | 1 | |||
| Subject . | Update or new recommendation . | Previous recommendation . | Number of studies . | Comments . |
|---|---|---|---|---|
| Adults with newly diagnosed ITP | ||||
| Prednisone or dexamethasone | Update | 2019 recommendation 4 | 3 | |
| H. pylori eradication | Update | 2011 recommendations 7.3.A and 7.3.B | 2 | |
| IVIg | Update | 2011 recommendation 4.3A | 2 | |
| Combination therapy | New | 3 | Agents used in combination with steroids: all-trans retinoic acid mycophenolate mofetil rhTPO | |
| Children with newly diagnosed ITP | ||||
| Observation or IVIg | Update | 2019 recommendation 12 | 3 | |
| Prednisone or dexamethasone | Update | 2019 recommendation 15 | 1 | |
| Anti-D immunoglobulin or IVIg | Update | 2019 recommendation 17 | 2 | |
| IVIg with or without IV methylprednisolone | New | 1 | ||
| Adults with ITP for ≥3 mo who are corticosteroid dependent or failed corticosteroids | ||||
| TPO-RAs (avatrombopag, eltrombopag, hetrombopag and romiplostim) | Update | 2019 recommendations 7 and 9 | 17 | |
| Low-dose Rituximab | Update | 2019 recommendations 8 and 9 | 1 | |
| Splenectomy | Update | 2019 recommendations 7 and 8 | 1 | |
| Fostamatinib | New | 3 | ||
| Rituximab with or without cyclophosphamide | New | 1 | ||
| Rituximab with or without all-trans retinoic acid | New | 1 | ||
| Danazol with or without all-trans retinoic acid | New | 1 | ||
| Hydroxychloroquine | New | 1 | ||
| IVIg or eltrombopag for surgery | New | 1 | ||
| Children with ITP who have non-threatening mucosal bleeding and/or diminished quality of life and do not respond to first-line treatment | ||||
| TPO-RAs (eltrombopag and romiplostim) | Update | 2019 recommendations 19 and 20 | 3 | 1 included in both adult and peds |
| TPO-RAs and Rituximab | Update | Recommendation 19 | 1 | |
| Splenectomy | Update | 2019 recommendations 20 and 21 | 1 | Included in both adult and peds |
| Sirolimus vs cyclosporine | New | 1 | ||
| Hydroxychloroquine | New | 1 | ||
| Multiple comparison studies | ||||
| Comparative effectiveness in children with ITP | 1 | |||
| Network meta-analysis in adults with ITP | 2 | |||
| Multiple agents single-center experience | 1 | |||