Trial-level R2 estimates for PFS: sensitivity analyses (all-NDMM population)
| Sensitivity analysis . | Total follow-up, mo (IQR) . | R2copula (95% CI) . | R2WLSiv (95% CI) . |
|---|---|---|---|
| Adding study 2.1 to all NDMM | 28.6 (19-56.4) | 0.82 (0.62-1.03) | 0.68 (0.45-0.91) |
| All NDMM without study 1.1A and 1.1B | 26.9 (18-53.4) | 0.72 (0.35->0.99) | 0.53 (0.22-0.83) |
| All NDMM without study 1.2 | 28.2 (18.8-55.6) | 0.87 (0.69->0.99) | 0.69 (0.47-0.92) |
| All NDMM without study 1.3 | 43.8 (24.3-61.1) | 0.91 (0.79->0.99) | 0.88 (0.78-0.98) |
| All NDMM without study 1.4 | 38 (18.9-59.5) | 0.82 (0.58->0.99) | 0.56 (0.27-0.86) |
| All NDMM without study 1.5 | 27.4 (18.1-58.9) | 0.84 (0.63->0.99) | 0.62 (0.36-0.89) |
| All NDMM without study 1.6 | 26.5 (18-44.4) | 0.88 (0.72->0.99) | 0.82 (0.67-0.96) |
| All NDMM without study 1.7 | 30.5 (18.9-58.3) | 0.78 (0.47->0.99) | 0.64 (0.39-0.9) |
| Sensitivity analysis . | Total follow-up, mo (IQR) . | R2copula (95% CI) . | R2WLSiv (95% CI) . |
|---|---|---|---|
| Adding study 2.1 to all NDMM | 28.6 (19-56.4) | 0.82 (0.62-1.03) | 0.68 (0.45-0.91) |
| All NDMM without study 1.1A and 1.1B | 26.9 (18-53.4) | 0.72 (0.35->0.99) | 0.53 (0.22-0.83) |
| All NDMM without study 1.2 | 28.2 (18.8-55.6) | 0.87 (0.69->0.99) | 0.69 (0.47-0.92) |
| All NDMM without study 1.3 | 43.8 (24.3-61.1) | 0.91 (0.79->0.99) | 0.88 (0.78-0.98) |
| All NDMM without study 1.4 | 38 (18.9-59.5) | 0.82 (0.58->0.99) | 0.56 (0.27-0.86) |
| All NDMM without study 1.5 | 27.4 (18.1-58.9) | 0.84 (0.63->0.99) | 0.62 (0.36-0.89) |
| All NDMM without study 1.6 | 26.5 (18-44.4) | 0.88 (0.72->0.99) | 0.82 (0.67-0.96) |
| All NDMM without study 1.7 | 30.5 (18.9-58.3) | 0.78 (0.47->0.99) | 0.64 (0.39-0.9) |
The 2004 comparison was not included in the primary analysis due to >20% of patients being assigned a value of missing for the primary end point definition based on MRD. All-NDMM (ie, TE and TIE combined) includes studies 1.1A, 1.1B, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.7. TE NDMM includes studies 1.1A, 1.1B, and 1.3.