Risk of VTE for patients with HAE stratified for age below or above 70 years in comparison with their nonaffected relatives
| . | Variable . | Person-years, no. . | Cases, no./persons at risk, no. . | Incidence rate, cases per 1000 person-years . | Incidence rate ratio (95% CI) . | HR (95% CI) . | |
|---|---|---|---|---|---|---|---|
| Model 1 . | Model 2 . | ||||||
| Follow-up ≤70 y | Non-HAE | 52 540 | 39/1259 | 0.74 (0.54-1.02) | 1 (reference) | 1 (reference) | 1 (reference) |
| HAE | 12 814 | 31/298 | 2.42 (1.70-3.44) | 3.26∗∗∗ (2.03-5.22) | 3.97∗∗∗ (2.50-6.30) | 3.62∗∗∗ (2.26-5.80) | |
| Follow-up >70 y | Non-HAE | 30 371 | 29/382 | 0.95 (0.66-1.37) | 1 (reference) | 1 (reference) | 1 (reference) |
| HAE | 5 316 | 4/67 | 0.75 (0.28-2.00) | 0.79 (0.28-2.24) | 0.81 (0.31-2.13) | 0.78 (0.30-2.02) | |
| . | Variable . | Person-years, no. . | Cases, no./persons at risk, no. . | Incidence rate, cases per 1000 person-years . | Incidence rate ratio (95% CI) . | HR (95% CI) . | |
|---|---|---|---|---|---|---|---|
| Model 1 . | Model 2 . | ||||||
| Follow-up ≤70 y | Non-HAE | 52 540 | 39/1259 | 0.74 (0.54-1.02) | 1 (reference) | 1 (reference) | 1 (reference) |
| HAE | 12 814 | 31/298 | 2.42 (1.70-3.44) | 3.26∗∗∗ (2.03-5.22) | 3.97∗∗∗ (2.50-6.30) | 3.62∗∗∗ (2.26-5.80) | |
| Follow-up >70 y | Non-HAE | 30 371 | 29/382 | 0.95 (0.66-1.37) | 1 (reference) | 1 (reference) | 1 (reference) |
| HAE | 5 316 | 4/67 | 0.75 (0.28-2.00) | 0.79 (0.28-2.24) | 0.81 (0.31-2.13) | 0.78 (0.30-2.02) | |
Time divided HRs (95% CI) were determined using extended Cox proportional hazards regression model (Heaviside functions). Model 1 is the univariate model. Model 2 is the multivariate model for HAE adjusted for sex, education, birth year, and country of birth.
The significance levels are indicated as follows: ∗∗∗P < .001.