Table 1.

Standardized SM screening and diagnostic testing implemented 1 July 2021

References
Screening tests  
1. Presence of monomorphic MPCM? (yes or no) 3,25  
2. Presence of high-risk anaphylaxis (REMA Score ≥ 2)? (yes or no) 27,54  
3. Elevated BST based upon tryptase genotype? (yes or no) 30,31  
Diagnostic testing quality checks  
1. Was high-sensitivity KIT p.D816V quantitative PCR performed? (yes or no) 37  
2. Was CD117, tryptase, CD25, CD2 IHC performed? (yes or no) 55  
3. Was mast cell flow cytometry performed? (yes or no) 56  
4. Was the BM analyzed at a center of excellence? (yes or no) 33,35,57  
References
Screening tests  
1. Presence of monomorphic MPCM? (yes or no) 3,25  
2. Presence of high-risk anaphylaxis (REMA Score ≥ 2)? (yes or no) 27,54  
3. Elevated BST based upon tryptase genotype? (yes or no) 30,31  
Diagnostic testing quality checks  
1. Was high-sensitivity KIT p.D816V quantitative PCR performed? (yes or no) 37  
2. Was CD117, tryptase, CD25, CD2 IHC performed? (yes or no) 55  
3. Was mast cell flow cytometry performed? (yes or no) 56  
4. Was the BM analyzed at a center of excellence? (yes or no) 33,35,57  

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