Multivariable Cox regression with time-dependent covariates
| Variable . | TFS . | TTFT . | ||
|---|---|---|---|---|
| HR . | P value . | HR . | P value . | |
| Age during diag. | 1.013 (1.009-1.018) | <.0001 | 0.974 (0.969-0.98) | <.0001 |
| Sex: male | 1.697 (1.52-1.896) | <.0001 | 1.236 (0.784-1.95) | .36 |
| Osteoporosis (binary) | 0.944 (0.825-1.08) | <.0001 | 0.452 (0.251-0.816) | .0083 |
| Binet stage = C | 1.95 (1.704-2.231) | <.0001 | 2.419 (1.186-4.935) | .015 |
| Albumin | 1.011 (0.996-1.025) | .165 | 1.041 (0.992-1.092) | .0954 |
| Calcium | 0.94 (0.897-0.985) | <.001 | 1.288 (0.983-1.687) | .069 |
| Elevated LDH∗ | 0.981 (0.854-1.127) | .786 | 0.958 (0.795-1.153) | .227 |
| Phosphore | 1.157 (1.051-1.274) | .003 | 1.271 (0.601-2.688) | .53 |
| Magnesium | 0.931 (0.754-1.151) | <.0001 | 0.902 (0.574-1.42) | .65 |
| PLT | 0.999 (0.998-1) | <.001 | 0.996 (0.991-1.001) | .062 |
| HB | 0.739 (0.723-0.754) | <.0001 | 0.733 (0.713-0.753) | <.0001 |
| Vitamin D 25 (OH) | 1.004 (0.998-1.009) | .177 | 1.0273 (1.0165-1.0382) | <.0001 |
| WBC | 1.002 (1.001-1.002) | <.0001 | 1.0023 (1.0020-1.0027) | <.0001 |
| % Lymp† | 1.001 (1.0004-91.0016) | .0001 | 1.004 (1.003-1.005) | <.0001 |
| Log (current vitamin D dose) | 0.912 (0.856-0.971) | .004 | 0.879 (0.762-1.014) | .077 |
| Log (current vitamin C dose) | 0.541 (0.052-5.603) | .615 | 0.6535 (0.129-3.302) | .607 |
| Variable . | TFS . | TTFT . | ||
|---|---|---|---|---|
| HR . | P value . | HR . | P value . | |
| Age during diag. | 1.013 (1.009-1.018) | <.0001 | 0.974 (0.969-0.98) | <.0001 |
| Sex: male | 1.697 (1.52-1.896) | <.0001 | 1.236 (0.784-1.95) | .36 |
| Osteoporosis (binary) | 0.944 (0.825-1.08) | <.0001 | 0.452 (0.251-0.816) | .0083 |
| Binet stage = C | 1.95 (1.704-2.231) | <.0001 | 2.419 (1.186-4.935) | .015 |
| Albumin | 1.011 (0.996-1.025) | .165 | 1.041 (0.992-1.092) | .0954 |
| Calcium | 0.94 (0.897-0.985) | <.001 | 1.288 (0.983-1.687) | .069 |
| Elevated LDH∗ | 0.981 (0.854-1.127) | .786 | 0.958 (0.795-1.153) | .227 |
| Phosphore | 1.157 (1.051-1.274) | .003 | 1.271 (0.601-2.688) | .53 |
| Magnesium | 0.931 (0.754-1.151) | <.0001 | 0.902 (0.574-1.42) | .65 |
| PLT | 0.999 (0.998-1) | <.001 | 0.996 (0.991-1.001) | .062 |
| HB | 0.739 (0.723-0.754) | <.0001 | 0.733 (0.713-0.753) | <.0001 |
| Vitamin D 25 (OH) | 1.004 (0.998-1.009) | .177 | 1.0273 (1.0165-1.0382) | <.0001 |
| WBC | 1.002 (1.001-1.002) | <.0001 | 1.0023 (1.0020-1.0027) | <.0001 |
| % Lymp† | 1.001 (1.0004-91.0016) | .0001 | 1.004 (1.003-1.005) | <.0001 |
| Log (current vitamin D dose) | 0.912 (0.856-0.971) | .004 | 0.879 (0.762-1.014) | .077 |
| Log (current vitamin C dose) | 0.541 (0.052-5.603) | .615 | 0.6535 (0.129-3.302) | .607 |
Diag., diagnosis; HB, hemoglobin; LDH, lactate dehydrogenase; Lymp, lymphocytes; PLT, platelet; WBC, white blood cells.
This variable refers to the logarithmic transformation of the current dose.
The variable %Lymp had a high VIF score and was suspected of multicollinearity, thus its hazard ratio and P value were calculated after removing ad hoc WBC (the corresponding variable with the highest correlation).