GA components and impairment thresholds
| Parameter . | Impairment threshold . | |
|---|---|---|
| Physical function | ||
| Timed up and go30 | ≥13.5 s | |
| Four-meter walk (gait speed)31 | Men (height): | |
| ≤173 cm: ≤0.65 m/s | ||
| >173 cm: ≤0.76 m/s | ||
| Women (height): | ||
| ≤159 cm: ≤0.65 m/s | ||
| >159 cm: ≤0.76 m/s | ||
| Six-minute walk32 | <400 m | |
| Grip strength33 | Cutoff criterion for impairment stratified by BMI and sex: | |
| Men BMI | Cutoff criterion | |
| ≤24 | ≤29 kg | |
| 24.1-26 | ≤30 kg | |
| 26.1-28 | ≤30 kg | |
| >28 | ≤32 kg | |
| Women BMI | Cutoff criterion | |
| ≤23 | ≤17 kg | |
| 23.1-26 | ≤17.3 kg | |
| 26.1-29 | ≤18 kg | |
| >29 | ≤21 kg | |
| Functional status | ||
| OARS IADL34 | <14 | |
| MOS physical health35 | <100 | |
| Self-reported Karnofsky performance status36 | <80 | |
| Physician-reported Karnofsky performance status37 | <80 | |
| Cognition | ||
| BOMC38 | ≥10 | |
| MOCA39 | <23 | |
| Mental Health Index-1740 | Scores ranged from 0 to 100. Impairment threshold not defined. | |
| Nutrition | ||
| Percent unintentional weight loss in last 6 mo41 | No weight loss vs 0.1-4.9 vs ≥5% | |
| Body mass index | <18.5 kg/m2 | |
| Prognostic Nutritional Index41,42,∗ | <44 | |
| Biomarkers | ||
| Albumin | <3.5 g/dL | |
| Ferritin | NA | |
| CRP | NA | |
| Parameter . | Impairment threshold . | |
|---|---|---|
| Physical function | ||
| Timed up and go30 | ≥13.5 s | |
| Four-meter walk (gait speed)31 | Men (height): | |
| ≤173 cm: ≤0.65 m/s | ||
| >173 cm: ≤0.76 m/s | ||
| Women (height): | ||
| ≤159 cm: ≤0.65 m/s | ||
| >159 cm: ≤0.76 m/s | ||
| Six-minute walk32 | <400 m | |
| Grip strength33 | Cutoff criterion for impairment stratified by BMI and sex: | |
| Men BMI | Cutoff criterion | |
| ≤24 | ≤29 kg | |
| 24.1-26 | ≤30 kg | |
| 26.1-28 | ≤30 kg | |
| >28 | ≤32 kg | |
| Women BMI | Cutoff criterion | |
| ≤23 | ≤17 kg | |
| 23.1-26 | ≤17.3 kg | |
| 26.1-29 | ≤18 kg | |
| >29 | ≤21 kg | |
| Functional status | ||
| OARS IADL34 | <14 | |
| MOS physical health35 | <100 | |
| Self-reported Karnofsky performance status36 | <80 | |
| Physician-reported Karnofsky performance status37 | <80 | |
| Cognition | ||
| BOMC38 | ≥10 | |
| MOCA39 | <23 | |
| Mental Health Index-1740 | Scores ranged from 0 to 100. Impairment threshold not defined. | |
| Nutrition | ||
| Percent unintentional weight loss in last 6 mo41 | No weight loss vs 0.1-4.9 vs ≥5% | |
| Body mass index | <18.5 kg/m2 | |
| Prognostic Nutritional Index41,42,∗ | <44 | |
| Biomarkers | ||
| Albumin | <3.5 g/dL | |
| Ferritin | NA | |
| CRP | NA | |
Older adult candidates for CAR-T therapy undergo the above battery of evaluations to inform the recommendation by the GA-MDC.
BMI, body mass index; BOMC, Blessed Orientation Memory Concentration test; MOS, Medical Outcomes Study; NA, not applicable; OARS IADL, Older Americans Resources and Services Instrumental Activities of Daily Living.
Prognostic nutritional index is calculated as 10 × serum albumin [g/dL] + (0.005 × lymphocytes/μL) and is unitless.