Systematic review question in PICOTS format
| Population | People without known hematologic malignancy |
| Index prognostic factor | CHIP: somatic mutations in myeloid-cancer-associated genes, VAF ≥2% (allow VAF ≥1%) |
| Comparator | People without CHIP, adjusted for age at a minimum |
| Outcomes | Clinical outcome including any disease entity |
| Timing | CHIP is measured at any time point in relation to outcome; any follow-up period |
| Setting | Variable (including community, primary care, hospital, and subpopulations) |
| Population | People without known hematologic malignancy |
| Index prognostic factor | CHIP: somatic mutations in myeloid-cancer-associated genes, VAF ≥2% (allow VAF ≥1%) |
| Comparator | People without CHIP, adjusted for age at a minimum |
| Outcomes | Clinical outcome including any disease entity |
| Timing | CHIP is measured at any time point in relation to outcome; any follow-up period |
| Setting | Variable (including community, primary care, hospital, and subpopulations) |