Baseline demographic and cardiac magnetic resonance characteristics at various time points
| Variable . | Baseline (N = 14) . | 1 mo after HCT (N = 10) . | 12 mo after HCT (N = 12) . |
|---|---|---|---|
| Demographics | |||
| Age at CMR, y | 14.1 (4.34) | 14.7 (4.46) | 15.6 (3.96) |
| Sex | |||
| F | 6 (42.9) | 4 (40.0) | 4 (33.3) |
| M | 8 (57.1) | 6 (60.0) | 8 (66.7) |
| Genotype | |||
| SS | 13 (92.9) | 9 (90.0) | 11 (91.7) |
| SC | 1 (7.1) | 1 (10.0) | 1 (8.3) |
| Weight, kg | 48.5 (17.5) | 48.0 (14.8) | 51.8 (17.8) |
| Height, cm | 154 (20.7) | 156 (21.3) | 158 (20.6) |
| BSA, m2 | 1.43 (0.358) | 1.44 (0.321) | 1.50 (0.354) |
| Heart rate at baseline, per min | 76.2 (13.8) | 76.5 (13.0) | 73.7 (13.9) |
| Hematocrit, % | 26.5 (3.03) | 31.4 (2.89) | 36.4 (3.22) |
| Graft source | |||
| Matched sibling | — | 5 (50.0) | 5 (41.7) |
| Haploidentical | — | 5 (50.0) | 7 (58.3) |
| CMR data | |||
| RVEF, % | 57.3 (6.29) | 57.1 (8.07) | 56.3 (6.32) |
| RVESVI, mL/m2 | 45.4 (13.2) | 39.1 (10.4)∗ | 41.7 (12.9) |
| RVEDVI, mL/m2 | 105 (17.3) | 90.6 (14.8)∗ | 94.0 (20.4)† |
| RVCI, L/min per m2 | 4.56 (1.16) | 3.89 (0.759)∗ | 3.85 (1.05)† |
| LVEF, % | 58.2 (3.40) | 55.9 (4.94) | 57.9 (3.34) |
| LVESVI, mL/m2 | 43.6 (8.36) | 40.6 (6.79) | 37.8 (8.26)† |
| LVEDVI, mL/m2 | 104 (16.3) | 92.8 (15.5)∗ | 89.3 (16.7)† |
| LVCI, L/min per m2 | 4.63 (1.24) | 3.94 (0.846)∗ | 3.78 (0.959)† |
| LVED mass I, g/m2 | 58.8 (12.5) | 57.0 (15.3) | 51.0 (9.80)† |
| LA volume, mL/m2 | 35.0 (6.66) | 31.1 (8.46) | 31.2 (7.26) |
| Native T1, ms | 1000 (55.4) | 999 (33.6) | 1000 (41.9) |
| Native T2, ms | 46.3 (3.01) | 45.0 (5.07) | 44.2 (2.46)† |
| T2∗, ms | 32.8 (5.48) | 34.7 (6.30) | 32.4 (7.40) |
| ECV, % | 30.3 (3.07) | 27.6 (3.72) | 27.1 (2.50)† |
| ECV ≥ 30 | |||
| Yes | 6 (42.9) | 2 (20.0) | 2 (16.7) |
| No | 8 (57.1) | 8 (80.0) | 10 (83.3) |
| Variable . | Baseline (N = 14) . | 1 mo after HCT (N = 10) . | 12 mo after HCT (N = 12) . |
|---|---|---|---|
| Demographics | |||
| Age at CMR, y | 14.1 (4.34) | 14.7 (4.46) | 15.6 (3.96) |
| Sex | |||
| F | 6 (42.9) | 4 (40.0) | 4 (33.3) |
| M | 8 (57.1) | 6 (60.0) | 8 (66.7) |
| Genotype | |||
| SS | 13 (92.9) | 9 (90.0) | 11 (91.7) |
| SC | 1 (7.1) | 1 (10.0) | 1 (8.3) |
| Weight, kg | 48.5 (17.5) | 48.0 (14.8) | 51.8 (17.8) |
| Height, cm | 154 (20.7) | 156 (21.3) | 158 (20.6) |
| BSA, m2 | 1.43 (0.358) | 1.44 (0.321) | 1.50 (0.354) |
| Heart rate at baseline, per min | 76.2 (13.8) | 76.5 (13.0) | 73.7 (13.9) |
| Hematocrit, % | 26.5 (3.03) | 31.4 (2.89) | 36.4 (3.22) |
| Graft source | |||
| Matched sibling | — | 5 (50.0) | 5 (41.7) |
| Haploidentical | — | 5 (50.0) | 7 (58.3) |
| CMR data | |||
| RVEF, % | 57.3 (6.29) | 57.1 (8.07) | 56.3 (6.32) |
| RVESVI, mL/m2 | 45.4 (13.2) | 39.1 (10.4)∗ | 41.7 (12.9) |
| RVEDVI, mL/m2 | 105 (17.3) | 90.6 (14.8)∗ | 94.0 (20.4)† |
| RVCI, L/min per m2 | 4.56 (1.16) | 3.89 (0.759)∗ | 3.85 (1.05)† |
| LVEF, % | 58.2 (3.40) | 55.9 (4.94) | 57.9 (3.34) |
| LVESVI, mL/m2 | 43.6 (8.36) | 40.6 (6.79) | 37.8 (8.26)† |
| LVEDVI, mL/m2 | 104 (16.3) | 92.8 (15.5)∗ | 89.3 (16.7)† |
| LVCI, L/min per m2 | 4.63 (1.24) | 3.94 (0.846)∗ | 3.78 (0.959)† |
| LVED mass I, g/m2 | 58.8 (12.5) | 57.0 (15.3) | 51.0 (9.80)† |
| LA volume, mL/m2 | 35.0 (6.66) | 31.1 (8.46) | 31.2 (7.26) |
| Native T1, ms | 1000 (55.4) | 999 (33.6) | 1000 (41.9) |
| Native T2, ms | 46.3 (3.01) | 45.0 (5.07) | 44.2 (2.46)† |
| T2∗, ms | 32.8 (5.48) | 34.7 (6.30) | 32.4 (7.40) |
| ECV, % | 30.3 (3.07) | 27.6 (3.72) | 27.1 (2.50)† |
| ECV ≥ 30 | |||
| Yes | 6 (42.9) | 2 (20.0) | 2 (16.7) |
| No | 8 (57.1) | 8 (80.0) | 10 (83.3) |
Data are given as mean (SD) or number (percentage).
BSA, body surface area; F, female; LA, left atrial; LVCI, left ventricular cardiac index; LVED mass I, left ventricular end-diastolic mass index; LVEDVI, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVI, left ventricular end-systolic volume index; M, male; RVCI, right ventricular cardiac index; RVEDVI, right ventricular end-diastolic volume index; RVEF, right ventricular ejection fraction; RVESVI, right ventricular end-systolic volume index.
Paired t test P ≤ .05 comparing 1-month post-HCT and baseline.
Paired t test P ≤ .05 comparing 12-month post-HCT and baseline.