Multivariate analysis of chronic GVHD with systemic steroid therapy in the BM/PB cohort
| Risk factors . | Adjustment for acute GVHD . | |||
|---|---|---|---|---|
| No . | Yes . | |||
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Acute GVHD | ||||
| None | NA | NA | Reference | 1.0 |
| Grade 1 | NA | NA | 1.32 (1.19-1.46) | <.001 |
| Grade 2 | NA | NA | 1.86 (1.70-2.04) | <.001 |
| Grade 3-4 | NA | NA | 1.90 (1.69-2.14) | <.001 |
| Age | ||||
| ≤56 y | 1.06 (0.97-1.15) | .19 | 1.08 (0.99-1.18) | .074 |
| 36-55 y | Reference | 1.0 | Reference | 1.0 |
| 16-35 y | 0.78 (0.71-0.86) | <.001 | 0.78 (0.71-0.86) | <.001 |
| Sex mismatch | ||||
| Match or male-to-female | Reference | 1.0 | Reference | 1.0 |
| Female-to-male | 1.49 (1.37-1.61) | <.001 | 1.49 (1.38-1.62) | <.001 |
| Disease risk index | ||||
| Low | Reference | 1.0 | Reference | 1.0 |
| Intermediate | 0.94 (0.82-1.08) | .37 | 0.95 (0.83-1.09) | .46 |
| High | 1.03 (0.89-1.19) | .72 | 1.01 (0.88-1.17) | .89 |
| Very high | 0.95 (0.77-1.17) | .62 | 0.91 (0.74-1.12) | .39 |
| HCT-CI | ||||
| 0-1 | Reference | 1.0 | Reference | 1.0 |
| ≥2 | 1.00 (0.92-1.09) | .92 | 1.01 (0.93-1.1) | .81 |
| Donor type | ||||
| Matched related | Reference | 1.0 | Reference | 1.0 |
| Matched unrelated | 0.96 (0.85-1.09) | .53 | 0.9 (0.79-1.02) | .10 |
| Mismatched unrelated | 1.12 (0.98-1.29) | .097 | 1.01 (0.87-1.16) | .95 |
| 1-locus MMRD | 1.04 (0.84-1.28) | .73 | 0.95 (0.76-1.17) | .61 |
| Haploidentical | 0.63 (0.54-0.73) | <.001 | 0.61 (0.52-0.71) | <.001 |
| Donor source | ||||
| BM | Reference | 1.0 | Reference | 1.0 |
| PB | 1.26 (1.14-1.39) | <.001 | 1.25 (1.13-1.38) | <.001 |
| Conditioning regimen | ||||
| MAC | Reference | 1.0 | Reference | 1.0 |
| RIC | 0.89 (0.82-0.97) | .0080 | 0.89 (0.82-0.97) | .0095 |
| GVHD prophylaxis | ||||
| CsA based | Reference | 1.0 | Reference | 1.0 |
| TAC based | 1.01 (0.91-1.12) | .82 | 1.06 (0.95-1.17) | .29 |
| In vivo T-cell depletion | ||||
| No | Reference | 1.0 | Reference | 1.0 |
| Yes | 0.71 (0.63-0.80) | <.001 | 0.72 (0.64-0.81) | <.001 |
| Risk factors . | Adjustment for acute GVHD . | |||
|---|---|---|---|---|
| No . | Yes . | |||
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Acute GVHD | ||||
| None | NA | NA | Reference | 1.0 |
| Grade 1 | NA | NA | 1.32 (1.19-1.46) | <.001 |
| Grade 2 | NA | NA | 1.86 (1.70-2.04) | <.001 |
| Grade 3-4 | NA | NA | 1.90 (1.69-2.14) | <.001 |
| Age | ||||
| ≤56 y | 1.06 (0.97-1.15) | .19 | 1.08 (0.99-1.18) | .074 |
| 36-55 y | Reference | 1.0 | Reference | 1.0 |
| 16-35 y | 0.78 (0.71-0.86) | <.001 | 0.78 (0.71-0.86) | <.001 |
| Sex mismatch | ||||
| Match or male-to-female | Reference | 1.0 | Reference | 1.0 |
| Female-to-male | 1.49 (1.37-1.61) | <.001 | 1.49 (1.38-1.62) | <.001 |
| Disease risk index | ||||
| Low | Reference | 1.0 | Reference | 1.0 |
| Intermediate | 0.94 (0.82-1.08) | .37 | 0.95 (0.83-1.09) | .46 |
| High | 1.03 (0.89-1.19) | .72 | 1.01 (0.88-1.17) | .89 |
| Very high | 0.95 (0.77-1.17) | .62 | 0.91 (0.74-1.12) | .39 |
| HCT-CI | ||||
| 0-1 | Reference | 1.0 | Reference | 1.0 |
| ≥2 | 1.00 (0.92-1.09) | .92 | 1.01 (0.93-1.1) | .81 |
| Donor type | ||||
| Matched related | Reference | 1.0 | Reference | 1.0 |
| Matched unrelated | 0.96 (0.85-1.09) | .53 | 0.9 (0.79-1.02) | .10 |
| Mismatched unrelated | 1.12 (0.98-1.29) | .097 | 1.01 (0.87-1.16) | .95 |
| 1-locus MMRD | 1.04 (0.84-1.28) | .73 | 0.95 (0.76-1.17) | .61 |
| Haploidentical | 0.63 (0.54-0.73) | <.001 | 0.61 (0.52-0.71) | <.001 |
| Donor source | ||||
| BM | Reference | 1.0 | Reference | 1.0 |
| PB | 1.26 (1.14-1.39) | <.001 | 1.25 (1.13-1.38) | <.001 |
| Conditioning regimen | ||||
| MAC | Reference | 1.0 | Reference | 1.0 |
| RIC | 0.89 (0.82-0.97) | .0080 | 0.89 (0.82-0.97) | .0095 |
| GVHD prophylaxis | ||||
| CsA based | Reference | 1.0 | Reference | 1.0 |
| TAC based | 1.01 (0.91-1.12) | .82 | 1.06 (0.95-1.17) | .29 |
| In vivo T-cell depletion | ||||
| No | Reference | 1.0 | Reference | 1.0 |
| Yes | 0.71 (0.63-0.80) | <.001 | 0.72 (0.64-0.81) | <.001 |
Abbreviations are explained in Table 1.
NA, Not available.