Treatment-related adverse events
| Toxicity type . | Treatment arms . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RB (n = 187) . | RBV (n = 185) . | LR (n = 147) . | R (n = 142) . | |||||||||
| Number of patients with each toxicity grade . | ||||||||||||
| 3 . | 4 . | 5 . | 3 . | 4 . | 5 . | 3 . | 4 . | 5 . | 3 . | 4 . | 5 . | |
| Anemia | 8 | — | — | 6 | 1 | — | 1 | — | — | 2 | — | — |
| Febrile neutropenia | 3 | 2 | — | 6 | — | — | 8 | 2 | — | 4 | 1 | — |
| Neutrophil count decreased | 21 | 18 | — | 38 | 14 | — | 43 | 43 | — | 13 | 15 | — |
| Platelet count decreased | 13 | 3 | — | 15 | 3 | — | 3 | 1 | — | — | 1 | — |
| Lung infection | 4 | — | — | 3 | — | — | 11 | 1 | — | 4 | 1 | — |
| Peripheral sensory neuropathy | — | — | — | 7 | — | — | 3 | — | — | 1 | — | — |
| Rash maculopopular | 7 | — | — | 11 | — | — | 4 | — | — | — | — | — |
| Toxicity type . | Treatment arms . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RB (n = 187) . | RBV (n = 185) . | LR (n = 147) . | R (n = 142) . | |||||||||
| Number of patients with each toxicity grade . | ||||||||||||
| 3 . | 4 . | 5 . | 3 . | 4 . | 5 . | 3 . | 4 . | 5 . | 3 . | 4 . | 5 . | |
| Anemia | 8 | — | — | 6 | 1 | — | 1 | — | — | 2 | — | — |
| Febrile neutropenia | 3 | 2 | — | 6 | — | — | 8 | 2 | — | 4 | 1 | — |
| Neutrophil count decreased | 21 | 18 | — | 38 | 14 | — | 43 | 43 | — | 13 | 15 | — |
| Platelet count decreased | 13 | 3 | — | 15 | 3 | — | 3 | 1 | — | — | 1 | — |
| Lung infection | 4 | — | — | 3 | — | — | 11 | 1 | — | 4 | 1 | — |
| Peripheral sensory neuropathy | — | — | — | 7 | — | — | 3 | — | — | 1 | — | — |
| Rash maculopopular | 7 | — | — | 11 | — | — | 4 | — | — | — | — | — |
Hematologic and any nonhematologic adverse event of grade ≥3 observed in >5% of a treatment arm.