Table 1. RBC abs and critical titers... | American Society of Hematology

Table 1.

RBC abs and critical titers according to Swedish national guidelines 2015

Risk for HDFN	Types of RBC abs
High risk	Anti-D
	Anti-K
	Anti-c
Moderate risk	Anti-C
	Anti-e
	Anti-E
	Anti-k
	Anti-Fya
	Anti-U
Low risk	Anti-Cw
	Anti-f
	Anti-Jka
	Anti-Jkb
	Anti-M
	Anti-Kpa
	Anti-Kpb
	Anti-Yta
	Anti-Coa
	Anti-Cob
	Anti-Ge2,3
Titer	Management implication
1-8	Not critical for the fetus, but an indication for continued surveillance with antibody titers. The exception is anti-K where monitoring with Doppler interrogation of MCA PSV should start at titer ≥8.
16-32	Low risk of severe HDFN, but neonatal hyperbilirubinemia requiring phototherapy is possible.
≥64	Close monitoring, including Doppler interrogation of MCA PSV. Risk of need for neonatal exchange transfusion.
≥128	Close monitoring, including Doppler interrogation of MCA PSV. Intrauterine blood transfusion/neonatal exchange transfusion may be required.

Risk for HDFN	Types of RBC abs
High risk	Anti-D
	Anti-K
	Anti-c
Moderate risk	Anti-C
	Anti-e
	Anti-E
	Anti-k
	Anti-Fya
	Anti-U
Low risk	Anti-Cw
	Anti-f
	Anti-Jka
	Anti-Jkb
	Anti-M
	Anti-Kpa
	Anti-Kpb
	Anti-Yta
	Anti-Coa
	Anti-Cob
	Anti-Ge2,3
Titer	Management implication
1-8	Not critical for the fetus, but an indication for continued surveillance with antibody titers. The exception is anti-K where monitoring with Doppler interrogation of MCA PSV should start at titer ≥8.
16-32	Low risk of severe HDFN, but neonatal hyperbilirubinemia requiring phototherapy is possible.
≥64	Close monitoring, including Doppler interrogation of MCA PSV. Risk of need for neonatal exchange transfusion.
≥128	Close monitoring, including Doppler interrogation of MCA PSV. Intrauterine blood transfusion/neonatal exchange transfusion may be required.

Reproduced from Liu et al,²⁴ with permission.

MCA, middle cerebral artery; PSV, peak systolic velocity.