Multivariate analysis of factors that affect 2-hour and 24-hour CCI
| Variable . | Estimate (range) . | P value . |
|---|---|---|
| 2 hours | ||
| Sum of MFIs | NA | 2.9E−10 |
| ABO mismatch (bidirectional/major) | −2 900.05 (−4 133.88 to −1 666.23) | 4.6E−06 |
| Platelet additive solution | −2 565.06 (−3 749.63 to −1 380.48) | 2.4E−05 |
| Transfusion reaction | −5 206.62 (−7 889.21 to −2 524.03) | 1.5E−04 |
| Spleen size (cm) | −787.48 (−1 224.35 to −350.61) | 4.3E−04 |
| Time since first HLA-selected transfusion | 0.37 (−0.02 to 0.77) | .07 |
| Baseline platelets >50 × 103/μL | 0.40 (−0.10 to 0.89) | .12 |
| Platelet component age | 14.44 (−4.27 to 33.15) | .13 |
| Patient sex (male) | −3 724.98 (−8 508.92 to 1 058.95) | .13 |
| Sepsis/infection/fever | −1 635.73 (−4 226.91 to 955.45) | .22 |
| cPRA, % | 32.49 (−19.56 to 84.54) | .22 |
| Major or minor bleeding | 1 616.27 (−1 589.92 to 4 822.45) | .32 |
| Antibiotics | −649.88 (−2 869.83 to 1 570.08) | .57 |
| HLA-selected components | 639.37 (−2 797.46 to 4 076.19) | .72 |
| DIC | −538.83 (−9 549.17 to 8 471.52) | .91 |
| Allogeneic HSCT | 94.11 (−2 600.11 to 2 788.33) | .95 |
| 24 hours | ||
| Platelet component age | 53.50 (18.07-88.92) | .003 |
| Sum of MFIs | −0.10 (−0.19 to −0.01) | .03 |
| Spleen size (cm) | −439.64 (−911.59 to 32.30) | .07 |
| Transfusion reaction | −4 429.94 (−10 144.53 to 1 284.65) | .13 |
| Time since first HLA-selected transfusion | 0.22 (−0.21 to 0.65) | .31 |
| Allogeneic HSCT | −1 690.57 (−5 001.89 to 1 620.76) | .32 |
| DIC | 5 582.28 (−5 425.35 to 16 589.90) | .32 |
| cPRA % | −30.13 (−91.80 to 31.54) | .34 |
| Platelet additive solution | −937.43 (−3 021.39 to 1 146.52) | .38 |
| Patient sex (male) | −1 940.74 (−6 286.36 to 2 404.87) | .39 |
| Sepsis/infection/fever | −1 457.98 (−5 194.48 to 2 278.52) | .44 |
| Antibiotics | −1 367.36 (−4 879.56 to 2 144.83) | .45 |
| Baseline platelets >50 × 103/μL | −620.44 (−3 016.83 to 1 775.96) | .61 |
| Major or minor bleeding | −374.23 (−4 694.77 to 3 946.31) | .87 |
| HLA-selected components | −327.94 (−4 760.14 to 4 104.25) | .88 |
| ABO mismatch (bidirectional/major) | −56.24 (−2 206.85 to 2 094.37) | .96 |
| Variable . | Estimate (range) . | P value . |
|---|---|---|
| 2 hours | ||
| Sum of MFIs | NA | 2.9E−10 |
| ABO mismatch (bidirectional/major) | −2 900.05 (−4 133.88 to −1 666.23) | 4.6E−06 |
| Platelet additive solution | −2 565.06 (−3 749.63 to −1 380.48) | 2.4E−05 |
| Transfusion reaction | −5 206.62 (−7 889.21 to −2 524.03) | 1.5E−04 |
| Spleen size (cm) | −787.48 (−1 224.35 to −350.61) | 4.3E−04 |
| Time since first HLA-selected transfusion | 0.37 (−0.02 to 0.77) | .07 |
| Baseline platelets >50 × 103/μL | 0.40 (−0.10 to 0.89) | .12 |
| Platelet component age | 14.44 (−4.27 to 33.15) | .13 |
| Patient sex (male) | −3 724.98 (−8 508.92 to 1 058.95) | .13 |
| Sepsis/infection/fever | −1 635.73 (−4 226.91 to 955.45) | .22 |
| cPRA, % | 32.49 (−19.56 to 84.54) | .22 |
| Major or minor bleeding | 1 616.27 (−1 589.92 to 4 822.45) | .32 |
| Antibiotics | −649.88 (−2 869.83 to 1 570.08) | .57 |
| HLA-selected components | 639.37 (−2 797.46 to 4 076.19) | .72 |
| DIC | −538.83 (−9 549.17 to 8 471.52) | .91 |
| Allogeneic HSCT | 94.11 (−2 600.11 to 2 788.33) | .95 |
| 24 hours | ||
| Platelet component age | 53.50 (18.07-88.92) | .003 |
| Sum of MFIs | −0.10 (−0.19 to −0.01) | .03 |
| Spleen size (cm) | −439.64 (−911.59 to 32.30) | .07 |
| Transfusion reaction | −4 429.94 (−10 144.53 to 1 284.65) | .13 |
| Time since first HLA-selected transfusion | 0.22 (−0.21 to 0.65) | .31 |
| Allogeneic HSCT | −1 690.57 (−5 001.89 to 1 620.76) | .32 |
| DIC | 5 582.28 (−5 425.35 to 16 589.90) | .32 |
| cPRA % | −30.13 (−91.80 to 31.54) | .34 |
| Platelet additive solution | −937.43 (−3 021.39 to 1 146.52) | .38 |
| Patient sex (male) | −1 940.74 (−6 286.36 to 2 404.87) | .39 |
| Sepsis/infection/fever | −1 457.98 (−5 194.48 to 2 278.52) | .44 |
| Antibiotics | −1 367.36 (−4 879.56 to 2 144.83) | .45 |
| Baseline platelets >50 × 103/μL | −620.44 (−3 016.83 to 1 775.96) | .61 |
| Major or minor bleeding | −374.23 (−4 694.77 to 3 946.31) | .87 |
| HLA-selected components | −327.94 (−4 760.14 to 4 104.25) | .88 |
| ABO mismatch (bidirectional/major) | −56.24 (−2 206.85 to 2 094.37) | .96 |
Factors that were significant predictors of CCI at 2 hours are in bold. Estimate and ranges for the sum of MFI are listed as NA because a nonlinear model was the best fit for this variable. P values were significant in the nonlinear model. Estimates are given in relationship to the associated variable. For continuous variables, the estimate is per 1 unit of the associated variable.
cPRA, calculated panel reactive antibody; DIC, disseminated intravascular coagulation; NA, not applicable.